Peer review

A technique utilizing crossing over between an A-B translocation (A1-B) and a reciprocal A translocation (A1-A2) to produce new “hybrid” A-B translocations is described. The BA element of these translocations consists of a portion of the original BA1 chromosome plus the A2 segment of the reciprocal A translocation (BA1A2). The remaining elements of the translocation consist of the A1B and A2A1 chromosomes. Eight new “hybrid” translocations are described. Three incorporate the long arm of chromosome 2, one the short arm of chromosome 2 and four the long arm of chromosome 4 as the A2 segment of the BA1A2 chromosome. These new translocations were used successively to locate genes in chromosome regions corresponding to the translocated A2 segments. Their usefulness in the cytological mapping of genes was also demonstrated.

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