Dwarf8 polymorphisms associate with variation in flowering time
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Nature Genetics v. 28, p. 286-289631087Summary: Historically, association tests have been used extensively in medical genetics1-2, but have had virtually no application in plant genetics. One obstacle to their application is the structured populations often found in crop plants3, which may lead to nonfunctional, spurious associations4, In this study, statistical methods to account for population structures were extended for use with quantitative variation and applied to our evaluation of maize flowering time, Mutagenesis and quantitative trait locus (QTL) studies suggested that the maize gene Dwarf8 might affect the quantitative variation of maize flowering time and plant height6-8, The wheat orthologs of this gene contributed to the increased yields seen in the 'Green Revolution' varieties6, We used association approaches to evaluate Dwarf8 sequence polymorphisms from 92 maize inbred lines. Population structure was esti- mated using a Bayesian analysis4 of 141 simple sequence repeat (SSR) loci. Our results indicate that a suite of polymor- phisms associate with differences in flowering time, which include a deletion that may alter a key domain in the coding region. The distribution of nonsynonymous polymorphisms suggests that DwarfS has been a target of selection.
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| Article | CIMMYT Knowledge Center: John Woolston Library | Reprints Collection | REP-9179 (Browse shelf(Opens below)) | 1 | Available | 631087 |
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Peer-review: Yes - Open Access: Yes|http://science.thomsonreuters.com/cgi-bin/jrnlst/jlresults.cgi?PC=MASTER&ISSN=1061-4036
Historically, association tests have been used extensively in medical genetics1-2, but have had virtually no application in plant genetics. One obstacle to their application is the structured populations often found in crop plants3, which may lead to nonfunctional, spurious associations4, In this study, statistical methods to account for population structures were extended for use with quantitative variation and applied to our evaluation of maize flowering time, Mutagenesis and quantitative trait locus (QTL) studies suggested that the maize gene Dwarf8 might affect the quantitative variation of maize flowering time and plant height6-8, The wheat orthologs of this gene contributed to the increased yields seen in the 'Green Revolution' varieties6, We used association approaches to evaluate Dwarf8 sequence polymorphisms from 92 maize inbred lines. Population structure was esti- mated using a Bayesian analysis4 of 141 simple sequence repeat (SSR) loci. Our results indicate that a suite of polymor- phisms associate with differences in flowering time, which include a deletion that may alter a key domain in the coding region. The distribution of nonsynonymous polymorphisms suggests that DwarfS has been a target of selection.
English
0203|AL-Maize Program|AL-Wheat Program|R01JOURN
Juan Carlos Mendieta
Reprints Collection
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