| 000 | 05498nab|a22010457a|4500 | ||
|---|---|---|---|
| 001 | 69464 | ||
| 003 | MX-TxCIM | ||
| 005 | 20251103130603.0 | ||
| 008 | 2510282025|||||xxu||p|op||||00||0|sengdd | ||
| 024 | 8 | _ahttps://doi.org/10.1101/2025.08.07.667917 | |
| 040 | _aMX-TxCIM | ||
| 041 | _aeng | ||
| 100 | 0 |
_aFanna Maina _940427 |
|
| 245 | 1 | 0 | _aDelivering trait-enhanced varieties to African smallholders through a pangenomic breeding network |
| 260 |
_aNueva York (United States of America) : _bbioRxiv, _c2025. |
||
| 500 | _aPreprint | ||
| 500 | _aOpen Access | ||
| 520 | _aPangenomics has been promoted to accelerate breeding of orphan crops, but smallholder farmers in developing nations have seen little benefit so far. To address this gap, we built a global pangenomic breeding network, integrating African breeding programs, U.S. land grant universities, and international nonprofit research organizations. Here we demonstrate that pangenomics, when integrated with local crop improvement knowledge and global scientific partnerships, can facilitate breeding of drought and pest resilient varieties for smallholders. To breed trait-enhanced sorghum varieties with lgs1-1 resistance to witchweed (Striga hermonthica) for smallholders in Niger, one of the world’s least developed nations, we used population genomics across local and global scales to develop lgs1-1 Striga resistance markers, and deployed them for rapid introgression of resistance into locally-preferred varieties. Genomic characterization, along with controlled experiments in laboratory, pot, field stations, and smallholder farms, confirmed lgs1-1 resistance was introgressed without loss of essential local-preference traits. New pangenomic resources, including global resequencing and graph pangenomes, further accelerated design of broadly-applicable markers. Unlocking the potential of pangenomics for stress-resilience breeding depended on stakeholder input, strong inference, South-led decision support software, and a dense collaborative network. The experience of the network provides a scalable roadmap for collaborative pangenomic breeding of trait-enhanced varieties for the world’s lowest-resourced farmers. | ||
| 546 | _aText in English | ||
| 597 |
_dUnited States Agency for International Development (USAID) _dBill & Melinda Gates Foundation (BMGF) |
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| 650 | 7 |
_aVarieties _2AGROVOC _91303 |
|
| 650 | 7 |
_aBreeding _2AGROVOC _91029 |
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| 650 | 7 |
_aSmallholders _2AGROVOC _91763 |
|
| 650 | 7 |
_aCrop improvement _2AGROVOC _91059 |
|
| 650 | 7 |
_aGenomic selection _2AGROVOC _91513 |
|
| 650 | 7 |
_aFood security _2AGROVOC _91118 |
|
| 651 | 7 |
_aAfrica _2AGROVOC _91316 |
|
| 700 | 1 |
_aFaye, J.M. _8001714758 _gDryland Crops Program _937348 |
|
| 700 | 1 |
_aKena, A.W. _940428 |
|
| 700 | 1 |
_aDiatta, C. _937120 |
|
| 700 | 0 |
_aMoctar Issiakou Tankari _940429 |
|
| 700 | 0 |
_aOusseini Abdou Ardaly _940430 |
|
| 700 | 0 |
_aOusmane Seyni Diakite _940431 |
|
| 700 | 0 |
_aAissata Mamadou Ibrahim _940432 |
|
| 700 | 0 |
_aOumarou Abdoulye Moussa _940433 |
|
| 700 | 0 |
_aAbdou Harou _940434 |
|
| 700 | 0 |
_aRabiou Abdou _940435 |
|
| 700 | 1 |
_aPascal Sene, J. _940436 |
|
| 700 | 0 |
_aSouleymane Bodian _940437 |
|
| 700 | 0 |
_aMbery Ndour _940438 |
|
| 700 | 0 |
_aDiarietou Sambakhe _940439 |
|
| 700 | 0 |
_aBassirou Sine _940440 |
|
| 700 | 0 |
_aPana Kadanga _940441 |
|
| 700 | 0 |
_aEyanawa Akata _940442 |
|
| 700 | 1 |
_aOuédraogo, N. _937125 |
|
| 700 | 1 |
_aAnnor, B. _96789 |
|
| 700 | 1 |
_aTetteh, I.T. _940443 |
|
| 700 | 0 |
_aMuhammad Ahmad Yahaya _930038 |
|
| 700 | 1 |
_aAbdoulaye Diallo _937232 |
|
| 700 | 1 |
_aKakeeto, R. _937707 |
|
| 700 | 1 |
_aKisilu, R. _937122 |
|
| 700 | 0 |
_aClarisse Pulchérie Kondombo _940444 |
|
| 700 | 0 |
_aTokuma Legesse _940445 |
|
| 700 | 1 |
_aMbulwe, L. _937123 |
|
| 700 | 1 |
_aMutaliano, J. _929688 |
|
| 700 | 1 |
_aMwenda, E.T. _932958 |
|
| 700 | 0 |
_aGapili Naoura _940446 |
|
| 700 | 0 |
_aHortense Noëlle Apala Mafouasson _940447 |
|
| 700 | 1 |
_aOpare-Obuobi, K. _940448 |
|
| 700 | 0 |
_aRekiya Otuchu Abdulmalik _940449 |
|
| 700 | 1 |
_aRuno, S. _917616 |
|
| 700 | 0 |
_aTilal Sayed Abdelhalim _940450 |
|
| 700 | 1 |
_aYalaukani, L. _937700 |
|
| 700 | 1 |
_aMasanga, J. _911059 |
|
| 700 | 1 |
_aMcLaughlin, C.M. _940451 |
|
| 700 | 1 |
_aLasky, J.R. _99592 |
|
| 700 | 1 |
_aHarder, A.M. _940452 |
|
| 700 | 1 |
_aHealey, A.L. _940453 |
|
| 700 | 0 |
_aLovell, J.T. _940454 |
|
| 700 | 1 |
_aOsei-Obeng, P. _940455 |
|
| 700 | 1 |
_aMarla, S.R. _940456 |
|
| 700 | 1 |
_aFelderhoff, T.J. _940457 |
|
| 700 | 1 |
_aHamidou, F. _92344 |
|
| 700 | 1 |
_aFoncéka, D. _926805 |
|
| 700 | 1 |
_aChejerla, M.K.V. _gDryland Crops Program _8001714111 _931909 |
|
| 700 | 1 |
_aNebie, B. _8001712983 _gGenetic Resources Program _gDryland Crops Program _930039 |
|
| 700 | 0 |
_aTamerlane Mark Nas _8001713621 _gGenetic Resources Program _gDryland Crops Program _931154 |
|
| 700 | 1 |
_8001711980 _aAlakonya, A. _gGenetic Resources Program _gDryland Crops Program _911060 |
|
| 700 | 1 |
_aRathore, A. _8001712937 _gExcellence in Breeding _gGenetic Resources Program _97897 |
|
| 700 | 1 |
_aDeshpande, S. _94852 |
|
| 700 | 1 |
_8001712882 _aGandhi, H. _gGenetic Resources Program _gDryland Crops Program _931144 |
|
| 700 | 1 |
_aBanda, L. _940458 |
|
| 700 | 1 |
_aRhodes, D.H. _94849 |
|
| 700 | 1 |
_aCruet-Burgos, C. _940459 |
|
| 700 | 1 |
_aVanGessel, C.J. _940460 |
|
| 700 | 1 |
_aMorris, G.P. _94848 |
|
| 773 | 0 |
_tbioRxiv _gIn press _dNueva York (United States of America) : bioRxiv, 2025. |
|
| 856 | 4 |
_yOpen Access through DSpace _uhttps://hdl.handle.net/10883/36005 |
|
| 942 |
_cJA _n0 _2ddc |
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| 999 |
_c69464 _d69456 |
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