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022			_a2223-7747 (Online)
024	8		_ahttps://doi.org/10.3390/plants14020295
040			_aMX-TxCIM
041			_aeng
100	1		_aMurithi, A. _98545
245	1	0	_aGlobal transcriptomic analysis of inbred lines reveal candidate genes for response to maize lethal necrosis
260			_aSwitzerland : _bMDPI, _c2025.
500			_aPeer review
500			_aOpen access
520			_aMaize lethal necrosis (MLN) is a significant threat to food security in Sub-Saharan Africa (SSA), with limited commercial inbred lines displaying tolerance. This study analyzed the transcriptomes of four commercially used maize inbred lines and a non-adapted inbred line, all with varying response levels to MLN. RNA-Seq revealed differentially expressed genes in response to infection by maize chlorotic mottle virus (MCMV) and sugarcane mosaic virus (SCMV), the causative agents of MLN. Key findings included the identification of components of the plant innate immune system, such as differentially regulated R genes (mainly LRRs), and activation/deactivation of virus resistance pathways, including RNA interference (RNAi) via Argonaute (AGO), Dicer-like proteins, and the ubiquitin–proteasome system (UPS) via RING/U-box and ubiquitin ligases. Genes associated with redox signaling, WRKY transcription factors, and cell modification were also differentially expressed. Additionally, the expression of translation initiation and elongation factors, eIF4E and eIF4G, correlated with the presence of MLN viruses. These findings provide valuable insights into the molecular mechanisms of MLN resistance and highlight potential gene candidates for engineering or selecting MLN-resistant maize germplasm for SSA.
546			_aText in English
591			_aMurithi, A. : Not in IRS Staff list but CIMMYT Affiliation
591			_aOlsen, M. : Not CIMMYT Affiliation
650		7	_aDisease resistance _2AGROVOC _91077
650		7	_aGene Expression _2AGROVOC _98835
650		7	_aMaize _2AGROVOC _91173
650		7	_aMaize chlorotic mottle virus _2AGROVOC _99361
650		7	_aNecrosis _2AGROVOC _91187
650		7	_aRNA Sequence _2AGROVOC _99041
650		7	_aSugarcane mosaic virus _2AGROVOC _912079
650		7	_aPlant viruses _2AGROVOC _91543
650		7	_aGenetic resistance _2AGROVOC _92277
700	0		_aGayathri Panangipalli _938184
700	0		_aZhengyu Wen _8001712121 _gGenetic Resources Program _95758
700	1		_aOlsen, M. _gGlobal Maize Program _8INT3333 _9923
700	1		_aLübberstedt, T. _98785
700	1		_8I1706696 _aDhugga, K. _gGenetic Resource Program _94340
700	1		_aJung, M. _938185
773	0		_dSwitzerland : MDPI, 2025. _gv. 14, no. 2, art. 295 _tPlants _x2223-7747
856	4		_yOpen Access through DSpace _uhttps://hdl.handle.net/10883/35474
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999			_c68612 _d68604