| 000 | 03748nab|a22004577a|4500 | ||
|---|---|---|---|
| 001 | 65763 | ||
| 003 | MX-TxCIM | ||
| 005 | 20231017232351.0 | ||
| 008 | 202212s2022||||mx |||p|op||||00||0|eng|d | ||
| 022 | _a1471-2229 | ||
| 024 | 8 | _ahttps://doi.org/10.1186/s12870-022-03932-y | |
| 040 | _aMX-TxCIM | ||
| 041 | _aeng | ||
| 100 | 1 |
_8001712108 _aBiswal, A.K. _gFormerly Genetic Resources Program _918209 |
|
| 245 | 1 | 0 |
_aMaize Lethal Necrosis disease : _breview of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa |
| 260 |
_bBioMed Central, _c2022. _aLondon (United Kingdom) : |
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| 500 | _aPeer review | ||
| 500 | _aOpen Access | ||
| 520 | _aBackground: Maize lethal necrosis (MLN) disease is a significant constraint for maize producers in sub-Saharan Africa (SSA). The disease decimates the maize crop, in some cases, causing total crop failure with far-reaching impacts on regional food security. Results: In this review, we analyze the impacts of MLN in Africa, finding that resource-poor farmers and consumers are the most vulnerable populations. We examine the molecular mechanism of MLN virus transmission, role of vectors and host plant resistance identifying a range of potential opportunities for genetic and phytosanitary interventions to control MLN. We discuss the likely exacerbating effects of climate change on the MLN menace and describe a sobering example of negative genetic association between tolerance to heat/drought and susceptibility to viral infection. We also review role of microRNAs in host plant response to MLN causing viruses as well as heat/drought stress that can be carefully engineered to develop resistant varieties using novel molecular techniques. Conclusions: With the dual drivers of increased crop loss due to MLN and increased demand of maize for food, the development and deployment of simple and safe technologies, like resistant cultivars developed through accelerated breeding or emerging gene editing technologies, will have substantial positive impact on livelihoods in the region. We have summarized the available genetic resources and identified a few large-effect QTLs that can be further exploited to accelerate conversion of existing farmer-preferred varieties into resistant cultivars. | ||
| 546 | _aText in English | ||
| 650 | 7 |
_aDrought stress _2AGROVOC _91081 |
|
| 650 | 7 |
_aGene editing _2AGROVOC _923072 |
|
| 650 | 7 |
_aMaize _2AGROVOC _91173 |
|
| 650 | 7 |
_aMaize _2AGROVOC _91173 |
|
| 650 | 7 |
_aNecrosis _2AGROVOC _91187 |
|
| 650 | 7 |
_aPotyvirus _2AGROVOC _913718 |
|
| 650 | 7 |
_aQuantitative Trait Loci _2AGROVOC _91853 |
|
| 651 | 7 |
_2AGROVOC _91950 _aAfrica South of Sahara |
|
| 700 | 1 |
_aAlakonya, A. _8001711980 _911060 _gGenetic Resources Program |
|
| 700 | 1 |
_aMottaleb, K.A. _gFormerly Socioeconomics Program _gFormerly Sustainable Agrifood Systems _8I1706152 _9810 |
|
| 700 | 1 |
_aHearne, S. _8INT3287 _9912 _gGenetic Resources Program |
|
| 700 | 1 |
_aSonder, K. _8INT3032 _9882 _gSocioeconomics Program _gSustainable Agrifood Systems |
|
| 700 | 1 |
_aMolnar, T.L. _8I1706071 _9802 _gFormerly Genetic Resources Program |
|
| 700 | 1 |
_aJones, A.M. _929362 |
|
| 700 | 1 |
_aPixley, K.V. _8INT1617 _9832 _gGenetic Resources Program |
|
| 700 | 1 |
_aPrasanna, B.M. _8INT3057 _9887 _gGlobal Maize Program |
|
| 773 | 0 |
_tBMC Plant Biology _gv. 22, no. 1, art. 542 _dLondon (United Kingdom) : BioMed Central, 2022. _wGu79387 _x1471-2229 |
|
| 856 |
_yOpen Access through DSpace _uhttps://hdl.handle.net/10883/22293 |
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| 942 |
_cJA _n0 _2ddc |
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| 999 |
_c65763 _d65755 |
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