000			02803nab|a22003977a|4500
001			64769
003			MX-TxCIM
005			20230105211134.0
008			202102s2018||||xxk|||p|op||||00||0|eng|d
022			_a2045-2322 (Online)
024	8		_ahttps://doi.org/10.1038/s41598-018-22103-4
040			_aMX-TxCIM
041			_aeng
100	1		_aMeale, S.J. _926213
245	1	0	_aFat accretion measurements strengthen the relationship between feed conversion efficiency and Nitrogen isotopic discrimination while rumen microbial genes contribute little
260			_aLondon (United Kingdom) : _bNature Publishing Group, _c2018.
500			_aPeer review
500			_aOpen Access
520			_aThe use of biomarkers for feed conversion efficiency (FCE), such as Nitrogen isotopic discrimination (Δ15N), facilitates easier measurement and may be useful in breeding strategies. However, we need to better understand the relationship between FCE and Δ15N, particularly the effects of differences in the composition of liveweight gain and rumen N metabolism. Alongside measurements of FCE and Δ15N, we estimated changes in body composition and used dietary treatments with and without nitrates, and rumen metagenomics to explore these effects. Nitrate fed steers had reduced FCE and higher Δ15N in plasma compared to steers offered non-nitrate containing diets. The negative relationship between FCE and Δ15N was strengthened with the inclusion of fat depth change at the 3rd lumbar vertebrae, but not with average daily gain. We identified 1,700 microbial genes with a relative abundance >0.01% of which, 26 were associated with Δ15N. These genes explained 69% of variation in Δ15N and showed clustering in two distinct functional networks. However, there was no clear relationship between their relative abundances and Δ15N, suggesting that rumen microbial genes contribute little to Δ15N. Conversely, we show that changes in the composition of gain (fat accretion) provide additional strength to the relationship between FCE and Δ15N.
546			_aText in English
591			_aSeetharam, K. : Not in IRS Staff list but CIMMYT Affiliation
650		7	_aGenes _2AGROVOC _93563
650		0	_aDNA Sequences _gAGROVOC _98666
650		7	_aMetabolism _2AGROVOC _910493
650		7	_aFats _2AGROVOC _917566
700	1		_aAuffret, M.D. _926214
700	1		_aWatson, M. _926215
700	1		_aMorgavi, D.P. _926216
700	1		_aCantalapiedra-Hijar, G. _926217
700	1		_aDuthie, C.A. _926218
700	1		_aRoehe, R. _926219
700	1		_aDewhurst, R.J. _926220
773	0		_gv. 8, art. 3854 _dLondon : Nature Publishing Group, 2018. _x2045-2322 _tNature Scientific Reports _wa58025
856	4		_yClick here to access online _uhttps://doi.org/10.1038/s41598-018-22103-4
942			_cJA _n0 _2ddc
999			_c64769 _d64761