000			02960nab a22004097a 4500
001			64732
003			MX-TxCIM
005			20230313165819.0
008			200115s2019 sz |||p|op||| 00| 0 eng d
022			_a1422-0067 (Online)
024	8		_ahttps://doi.org/10.3390/ijms20092137
040			_aMX-TxCIM
041			_aeng
100	1		_926063 _aNielsen, T.S.
245	1	0	_aHigh-amylose maize, potato, and butyrylated starch modulate large intestinal fermentation, microbial composition, and oncogenic miRNA expression in rats fed a high-protein meat diet
260			_aBasel (Switzerland) : _bMDPI, _c2019.
500			_aPeer review
500			_aOpen Access
520			_aHigh red meat intake is associated with the risk of colorectal cancer (CRC), whereas dietary fibers, such as resistant starch (RS) seemed to protect against CRC. The aim of this study was to determine whether high-amylose potato starch (HAPS), high-amylose maize starch (HAMS), and butyrylated high-amylose maize starch (HAMSB)—produced by an organocatalytic route—could oppose the negative effects of a high-protein meat diet (HPM), in terms of fermentation pattern, cecal microbial composition, and colonic biomarkers of CRC. Rats were fed a HPM diet or an HPM diet where 10% of the maize starch was substituted with either HAPS, HAMS, or HAMSB, for 4 weeks. Feces, cecum digesta, and colonic tissue were obtained for biochemical, microbial, gene expression (oncogenic microRNA), and immuno-histochemical (O6-methyl-2-deoxyguanosine (O6MeG) adduct) analysis. The HAMS and HAMSB diets shifted the fecal fermentation pattern from protein towards carbohydrate metabolism. The HAMSB diet also substantially increased fecal butyrate concentration and the pool, compared with the other diets. All three RS treatments altered the cecal microbial composition in a diet specific manner. HAPS and HAMSB showed CRC preventive effects, based on the reduced colonic oncogenic miR17-92 cluster miRNA expression, but there was no significant diet-induced differences in the colonic O6MeG adduct levels. Overall, HAMSB consumption showed the most potential for limiting the negative effects of a high-meat diet.
546			_aText in English
650		7	_2AGROVOC _918845 _aButyrates
650		7	_2AGROVOC _95810 _aStarch
650		7	_2AGROVOC _926064 _aColon
650		7	_2AGROVOC _926065 _aShort chain fatty acids
650		0	_aMicroorganisms _gAGROVOC _910080
650		7	_2AGROVOC _922453 _amicroRNA
650		7	_2AGROVOC _913434 _aDNA
700	1		_926066 _aBendiks, Z.
700	1		_926067 _aThomsen, B.
700	1		_926068 _aWright, M.E.
700	1		_926069 _aTheil, P.K.
700	1		_926070 _aScherer, B.L.
700	1		_926071 _aMarco, M.L.
773	0		_dBasel (Switzerland) : MDPI, 2019. _gv. 20, no. 9, art. 2137 _tInternational Journal of Molecular Sciences _w57216 _x1422-0067
856	4		_yClick here to access online _uhttps://doi.org/10.3390/ijms20092137
942			_2ddc _cJA _n0
999			_c64732 _d64724