000			03398nab a22003977a 4500
001			64691
003			MX-TxCIM
005			20211213160307.0
008			200115s2021 sz |||p|op||| 00| 0 eng d
022			_a2076-2615 (Online)
024	8		_ahttps://doi.org/10.3390/ani11020359
040			_aMX-TxCIM
041			_aeng
100	0		_925818 _aDongxu Ming
245	1	0	_aEffects of diet supplemented with excess pyrroloquinoline quinone disodium on growth performance, blood parameters and redox status in weaned pigs
260			_aBasel (Switzerland) : _bMDPI, _c2021.
500			_aPeer review
500			_aOpen Access
520			_aThe research was implemented to assess the safety of feeding excess of pyrroloquinoline quinone disodium (PQQ·Na2) to 108 Duroc × Landrace × Large White weaned pigs (BW = 8.38 ± 0.47 kg). Pigs were weaned at 28 d and randomly distributed to one of three diets with six replicates and six pigs per replicate (three males and three females). Pigs in the control group were fed a corn-soybean meal-based diet (without growth promoter) while the two experimental diets were supplied with 7.5 and 75.0 mg/kg PQQ·Na2, respectively. Average daily gain (ADG), average daily feed intake (ADFI), feed conversion (F:G), diarrhea incidence, hematology, serum biochemistry, organ index and general health were determined. Diets supplementation with 7.5 mg/kg PQQ·Na2 in weaned pigs could increase ADG during the entire experimental period (p < 0.05). And there was a tendency to decrease F:G (p = 0.063). The F:G of weaned pigs fed 7.5 and 75.0 mg/kg PQQ·Na2 supplemented diets was decreased by 9.83% and 8.67%, respectively, compared to the control group. Moreover, pigs had reduced diarrhea incidence (p < 0.01) when supplemented with PQQ·Na2. No differences were observed between pigs supplemented with 0.0, 7.5 and 75.0 mg/kg PQQ·Na2 diets on hematological and serum biochemical parameters as well as histological assessment of heart, liver, spleen, lung and kidney. At day 14, pigs had increased activity of glutathione peroxidase (GSH-Px) (p < 0.05), catalase (CAT) (p < 0.05) and total antioxidant capacity (T-AOC) (p < 0.05), and the serum concentration of malondialdehyde (MDA) was decreased (p < 0.01) with PQQ·Na2 supplementation. At day 28, pigs had increased activities of total superoxide dismutase (T-SOD) (p < 0.01), GSH-Px (p < 0.01), CAT (p < 0.05) and T-AOC (p < 0.01), and serum concentration of MDA was lower (p < 0.01) with PQQ·Na2 supplementation. In conclusion, PQQ·Na2 can improve weaned pigs growth performance and serum antioxidant status. Meanwhile high PQQ·Na2 inclusion of 75.0 mg/kg does not appear to result in harmful effects on growth performance of pigs.
546			_aText in English
650		7	_2AGROVOC _925819 _aQuinones
650		7	_2AGROVOC _99791 _aSafety
650		7	_2AGROVOC _924513 _aRedox potential
650		7	_2AGROVOC _925820 _aWeaners
700	0		_925821 _aCaiyun Huang
700	0		_925822 _aWenhui Wang
700	0		_925823 _aZijie Wang
700	0		_925824 _aChenyu Shi
700	0		_925825 _aXindi Yin
700	0		_925826 _aLinlin Sun
700	0		_925827 _aYoujun Gao
700	0		_925828 _aFenglai Wang
773	0		_dBasel (Switzerland) : MDPI, 2021. _gv. 11, no. 2, art. 359 _tAnimals _x2076-2615
856	4		_yClick here to access online _uhttps://doi.org/10.3390/ani11020359
942			_2ddc _cJA _n0
999			_c64691 _d64683