000			03000nab|a22003497a|4500
001			64675
003			MX-TxCIM
005			20211213155855.0
008			200416s2017||||cc |||p|op||||00||0|eng|d
022			_a1672-0229
024	8		_ahttps://doi.org/10.1016/j.gpb.2016.06.003
040			_aMX-TxCIM
041			_aeng
100	1		_aRamírez-Sánchez, O. _914814
245	1	0	_aPlant proteins are smaller because they are encoded by fewer exons than animal proteins
260			_aChina : _bElsevier, _c2016.
500			_aPeer review
500			_aOpen Access
520			_aProtein size is an important biochemical feature since longer proteins can harbor more domains and therefore can display more biological functionalities than shorter proteins. We found remarkable differences in protein length, exon structure, and domain count among different phylogenetic lineages. While eukaryotic proteins have an average size of 472 amino acid residues (aa), average protein sizes in plant genomes are smaller than those of animals and fungi. Proteins unique to plants are ∼81 aa shorter than plant proteins conserved among other eukaryotic lineages. The smaller average size of plant proteins could neither be explained by endosymbiosis nor subcellular compartmentation nor exon size, but rather due to exon number. Metazoan proteins are encoded on average by ∼10 exons of small size [∼176 nucleotides (nt)]. Streptophyta have on average only ∼5.7 exons of medium size (∼230 nt). Multicellular species code for large proteins by increasing the exon number, while most unicellular organisms employ rather larger exons (>400 nt). Among subcellular compartments, membrane proteins are the largest (∼520 aa), whereas the smallest proteins correspond to the gene ontology group of ribosome (∼240 aa). Plant genes are encoded by half the number of exons and also contain fewer domains than animal proteins on average. Interestingly, endosymbiotic proteins that migrated to the plant nucleus became larger than their cyanobacterial orthologs. We thus conclude that plants have proteins larger than bacteria but smaller than animals or fungi. Compared to the average of eukaryotic species, plants have ∼34% more but ∼20% smaller proteins. This suggests that photosynthetic organisms are unique and deserve therefore special attention with regard to the evolutionary forces acting on their genomes and proteomes.
546			_aText in English
591			_aGuzman, C. : No CIMMYT Affiliation
650		7	_2AGROVOC _925734 _aEukaryota
650		7	_2AGROVOC _98815 _aEvolution
650		7	_2AGROVOC _925735 _aPolypeptide
650		7	_2AGROVOC _91224 _aProteins
700	1		_aPerez-Rodriguez, P. _92703
700	1		_aDelaye, L. _925736
700	1		_aTiessen, A. _97660
773	0		_tGenomics, Proteomics & Bioinformatics _gv. 14, no. 6, p. 357-370 _dChina : Elsevier, 2016. _x1672-0229
856	4		_uhttps://doi.org/10.1016/j.gpb.2016.06.003 _yOpen Access through DSpace
942			_cJA _n0 _2ddc
999			_c64675 _d64667