000			02902nab a22003377a 4500
001			64439
003			MX-TxCIM
005			20211101203245.0
008			201218s2021 xxu|||p|op||| 00| 0 eng d
022			_a0013-9351
024	8		_ahttps://doi.org/10.1016/j.envres.2021.112012
040			_aMX-TxCIM
041			_aeng
100	1		_aGuzmán, P. _924345
245	1	0	_aEffects of air pollution on dementia over Europe for present and future climate change scenarios
260			_aUSA : _bElsevier, _c2021.
500			_aPeer review
500			_aOpen Access
520			_aThe scientific literature is scarce when referring to the influence of atmospheric pollutants on neurodegenerative diseases for present and future climate change scenarios. In this sense, this contribution evaluates the incidence of dementia (Alzheimer's disease, AD, and dementia from unspecified cause, DU) occurring in Europe associated with the exposure to air pollution (essentially NO2 and PM2.5) for the present climatic period (1991–2010) and for a future climate change scenario (RCP8.5, 2031–2050). The GEMM methodology has been applied to air pollution simulations using the chemistry/climate regional model WRF-Chem. Present population data were obtained from NASA's Center for Socioeconomic Data and Applications (SEDAC); while future population projections for the year 2050 were derived from the United Nations (UN) Department of Economic and Social Affairs-Population Dynamics. Overall, the estimated incidence rate (cases per year) of AD and DU associated with exposure to air pollution over Europe is 498,000 [95% confidence interval (95% CI) 348,600–647,400] and 314,000 (95% CI 257,500-401,900), respectively. An important increase in the future incidence rate is projected (around 72% for both types of dementia) when considering the effect of climate change together with the foreseen changes in the future population, because of the expected aging of European population. The climate penalty (impacts of future climate change alone on air quality) has a limited effect on the total changes of dementia (approx. 0.5%), because the large increase in the incidence rate over southern Europe is offset by its decrease over more northern countries, favored by an improvement of air pollution caused by the projected enhancement of rainfall.
546			_aText in English
650		7	_2AGROVOC _97239 _aAir pollution
650		7	_2AGROVOC _924346 _aNervous system diseases
650		7	_2AGROVOC _914105 _aAerosols
650		7	_2AGROVOC _919263 _aMental health
700	1		_aTarín-Carrasco, P. _924347
700	1		_aMorales-Suárez-Varela, M. _924348
700	1		_aJiménez-Guerrero, P. _924349
773	0		_tEnvironmental Research _gv. 204, art. 112012 _dUSA : Elsevier, 2021. _x0013-9351
856	4		_uhttps://doi.org/10.1016/j.envres.2021.112012 _yClick here to access online
942			_cJA _n0 _2ddc
999			_c64439 _d64431