000			00595nab|a22002177a|4500
999			_c63944 _d63936
001			63944
003			MX-TxCIM
005			20210719145010.0
008			200214s2021||||xxk|||p|op||||00||0|eng|d
022			_a1471-2164 (Online)
024	8		_ahttps://doi.org/10.1186/s12864-021-07800-1
040			_aMX-TxCIM
041			_aeng
100	1		_aBuerstmayr, M. _921257
245	1	0	_aFusarium head blight resistance in European winter wheat : _binsights from genome-wide transcriptome analysis
260			_aLondon (United Kingdom) : _bBioMed Central, _c2021.
500			_aPeer review
500			_aOpen Access
520			_aBackground: Fusarium head blight (FHB) is a devastating disease of wheat worldwide. Resistance to FHB is quantitatively controlled by the combined effects of many small to medium effect QTL. Flowering traits, especially the extent of extruded anthers, are strongly associated with FHB resistance. Results: To characterize the genetic basis of FHB resistance, we generated and analyzed phenotypic and gene expression data on the response to Fusarium graminearum (Fg) infection in 96 European winter wheat genotypes, including several lines containing introgressions from the highly resistant Asian cultivar Sumai3. The 96 lines represented a broad range in FHB resistance and were assigned to sub-groups based on their phenotypic FHB severity score. Comparative analyses were conducted to connect sub-group-specific expression profiles in response to Fg infection with FHB resistance level. Collectively, over 12,300 wheat genes were Fusarium responsive. The core set of genes induced in response to Fg was common across different resistance groups, indicating that the activation of basal defense response mechanisms was largely independent of the resistance level of the wheat line. Fg-induced genes tended to have higher expression levels in more susceptible genotypes. Compared to the more susceptible non-Sumai3 lines, the Sumai3-derivatives demonstrated higher constitutive expression of genes associated with cell wall and plant-type secondary cell wall biogenesis and higher constitutive and Fg-induced expression of genes involved in terpene metabolism. Gene expression analysis of the FHB QTL Qfhs.ifa-5A identified a constitutively expressed gene encoding a stress response NST1-like protein (TraesCS5A01G211300LC) as a candidate gene for FHB resistance. NST1 genes are key regulators of secondary cell wall biosynthesis in anther endothecium cells. Whether the stress response NST1-like gene affects anther extrusion, thereby affecting FHB resistance, needs further investigation. Conclusion: Induced and preexisting cell wall components and terpene metabolites contribute to resistance and limit fungal colonization early on. In contrast, excessive gene expression directs plant defense response towards programmed cell death which favors necrotrophic growth of the Fg pathogen and could thus lead to increased fungal colonization.
546			_aText in English
650		7	_2AGROVOC _91296 _aTriticum aestivum
650		7	_2AGROVOC _92331 _aGibberella zeae
650		7	_2AGROVOC _98684 _aCell Walls
650		7	_2AGROVOC _921268 _aTerpenoids
650		7	_2AGROVOC _99041 _aRNA Sequence
700	1		_aWagner, C. _921258
700	1		_aNosenko, T. _921259
700	1		_aOmony, J. _921260
700	1		_aSteiner, B. _921261
700	1		_aNussbaumer, T. _921262
700	1		_aMayer, K.F.X. _917431
700	1		_aBuerstmayr, H. _921263
773	0		_tBMC Genomics _gv. 22, art. 470 _dLondon (United Kingdom) : BioMed Central, 2021. _x1471-2164 _wu56896
856	4		_yClick here to access online _uhttps://doi.org/10.1186/s12864-021-07800-1
942			_cJA _n0 _2ddc