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005			20211006085227.0
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022			_a2045-2322
024	8		_ahttps://doi.org/10.1038/s41598-021-83751-7
040			_aMX-TxCIM
041			_aeng
100	1		_aKortei, N.K. _919798
245	1	4	_aThe occurrence of aflatoxins and human health risk estimations in randomly obtained maize from some markets in Ghana
260			_aLondon (United Kingdom) : _bNature Publishing Group, _c2021.
500			_aPeer review
500			_aOpen Access
520			_aMaize and its products are most often prone to fungal contamination especially during cultivation and storage by toxigenic fungi. Aflatoxicosis still persist in Ghana despite the numerous education on several ways of its prevention at the farm as well as its adverse health implications which are food safety concerns. A random assessment and human risk analysis was conducted on 90 maize (72 white and 18 colored) samples from markets across all the regions of Ghana. Total aflatoxins (AFtotal) and the constitutive aflatoxins (AFB1, AFB2, AFG1, and AFG2) were analyzed by High-Performance Liquid Chromatography (HPLC). Out of a total of ninety (90) samples investigated, 72 (80%) tested positive for AFB1 and the contamination levels ranged from 0.78 ± 0.04 to 339.3 ± 8.6 µg kg−1. Similarly, AFG2 was detected in only 14 (15.5%) samples, and their values ranged between 1.09 ± 0.03 and 5.51 ± 0.26 µg kg−1 while AF total ranged between 0.78 ± 0.04 and 445.01 ± 8.9 µg kg−1 constituting approximately 72 (80%). Limits of AFB1 and total aflatoxins (AFtotal) for the Ghana Standards Authority (GSA) (5 and 10 µg kg−1) and the European Food Safety Authority (EFSA) (2 and 4 µg kg−1), were used as checks. A total of 33 (41.25%) samples were above the limits for both. Risk assessments recorded for Estimated Daily Intake (EDI), Hazard Quotient (H.Q), Hazard Index (H.I), Margin of Exposure (MOE), av. Potency, and population risks ranged 0.087–0.38 μg kg−1 bw day−1, 1.5–6.9, 0.0087–0.38, 3.64–12.09, 0–0.0396 ng Aflatoxins kg−1 bw day−1 and, 3.5 × 10–1–0.015 respectively for total aflatoxins. While ranges for aflatoxins B1 (AFB1) recorded were 0.068–0.3 μg Kg bw−1 day−1, 2.43–10.64, 0.0068–0.030, 4.73–20.51, 0–0.0396 ng Aflatoxins kg−1 bw day−1 and, 2.69 × 10–3–0.012 for Estimated Daily Intake (EDI), Hazard Quotient (H.Q), Hazard Index (H.I), Margin of Exposure (MOE), Av. potency, and population risks respectively. It was deduced that although there was some observed contamination of maize across the different ecological zones, the consumption of maize (white and colored) posed no adverse health effects on the population of Ghana since computed H.I was less than 1 (< 1).
546			_aText in English
650		7	_aAflatoxins _2AGROVOC _95637
650		7	_aMaize _gAGROVOC _2 _91173
650		7	_aHealth _2AGROVOC _94222
651		7	_2AGROVOC _94493 _aGhana
700	1		_aAnnan, T. _919799
700	1		_aAkonor, P.T. _919800
700	1		_aRichard, S.A. _919801
700	1		_aAnnan, H.A. _919802
700	1		_aKyei-Baffour, V. _919803
700	1		_aAkuamoa, F. _919804
700	1		_aAkpaloo, P.G. _919805
700	1		_aEsua-Amoafo, P. _919806
773	0		_gv. 11, art. 4295 _dLondon (United Kingdom) : Nature Publishing Group, 2021. _x2045-2322 _tNature Scientific Reports _wa58025
856	4		_yClick here to access online _uhttps://doi.org/10.1038/s41598-021-83751-7
942			_cJA _n0 _2ddc