000			00595nab|a22002177a|4500
999			_c62645 _d62637
001			62645
003			MX-TxCIM
005			20201002223537.0
008			200910s2020||||xxk|||p|op||||00||0|eng|d
022			_a0968-0896
024	8		_ahttps://doi.org/10.1016/j.bmc.2020.115725
040			_aMX-TxCIM
041			_aeng
100	1		_aFrackenpohl, J. _916212
245	1	0	_aTetrahydroquinolinyl phosphinamidates and phosphonamidates enhancing tolerance towards drought stress in crops via interaction with ABA receptor proteins
260			_aUnited Kingom : _bElsevier, _c2020.
500			_aPeer review
520			_aNew phosphorous-containing lead structures against drought stress in crops interacting with RCAR/(PYR/PYL) receptor proteins were identified starting from in-depth SAR studies of related sulfonamide lead structures and protein docking studies. A converging 6-step synthesis via phosphinic chlorides and phosphono chloridates as key intermediates afforded envisaged tetrahydroquinolinyl phosphinamidates and phosphonamidates. Whilst tetrahydroquinolinyl phosphonamidates 13a,b exhibited low to moderate target affinities, the corresponding tetrahydroquinolinyl phosphinamidates 12a,b revealed confirmed strong affinities for RCAR/ (PYR/PYL) receptor proteins in Arabidopsis thaliana on the same level as essential plant hormone abscisic acid (ABA) combined with promising efficacy against drought stress in vivo (broad-acre crops wheat and canola).
546			_aText in English
650		7	_2AGROVOC _911179 _aPhytochemistry
650		7	_2AGROVOC _91081 _aDrought stress
650		7	_2AGROVOC _93517 _aABA
700	1		_916213 _aDecker, L.J.B.
700	1		_916214 _aDittgen, J.
700	1		_916215 _aFreigang, J.
700	1		_916216 _aGénix, P.
700	1		_916217 _aHelmke, H.
700	1		_916218 _aLange, G.
700	1		_916219 _aLuemmen, P.
700	1		_916220 _aSchmidt, J.
700	1		_916221 _aSchmutzler, D.
700	1		_916222 _aVors, J.
773	0		_tBioorganic and Medicinal Chemistry _gv. 28, no. 22, art. 115725 _dUnited Kingdom : Elsevier, 2020. _x0968-0896
942			_cJA _n0 _2ddc