000			nab a22 7a 4500
999			_c59836 _d59828
001			59836
003			MX-TxCIM
005			20191122160953.0
008			181108s2018||||ohu|||p|op||||00||0|eng|d
024	8		_ahttps://doi.org/10.1021/acs.jnatprod.8b00486
040			_aMX-TxCIM
041			_aeng
100	1		_aHelaly, S.E. _98155
245	1		_aNematicidal cyclic lipodepsipeptides and a xanthocillin derivative from a phaeosphariaceous fungus parasitizing eggs of the plant parasitic nematode Heterodera filipjevi
260			_bAmerican Chemical Society, _c2018. _aOhio, U.S. :
500			_aPeer review
520			_aThe new cyclic lipodepsipeptide ophiotine (1), two new arthrichitin derivatives named arthrichitins B (4) and C (5), a new xanthocillin-like alkaloid, xanthomide Z (2), and the previously described arthrichitin (3) were isolated from the liquid culture broth of a nematode-associated fungus with affinities to the genus Ophiosphaerella. The structural elucidation and determination of the absolute configuration of the new molecules were accomplished using a combination of spectroscopic and chemical techniques, including 1D and 2D NMR, HRMS, and Marfey's analysis. Opiotine (1) displayed moderate nematicidal activity against the host nematode (Heterodera filipjevi), while xanthomide Z (2) exhibited very weak activity. Arthrichitin C (5) showed very weak cytotoxic effects on several cancer cell lines, with IC50 values in the range of 24-33 ?M. Xanthomide Z is among few xanthocillin derivatives that comprise formamide functions instead of the cyano functions that are usually observed in this class of fungal alkaloids.
546			_aText in English
650		7	_2AGROVOC _95669 _aDisease control
650		7	_2AGROVOC _94804 _aPlant nematodes
650		7	_91796 _aHeterodera _2AGROVOC
700	1		_aAshrafi, S. _9419
700	1		_aTeponno, R.B. _98156
700	1		_aBernecker, S. _98157
700	1		_9874 _aDababat, A.A. _gGlobal Wheat Program _8INT2918
700	1		_9190 _aMaier, W.
700	1		_95109 _aStadler, M.
773	0		_tJournal of Natural Products _gv. 81, no. 10, p. 2228-2234 _x0163-3864 (Print) 1520-6025 (Online)
856	4		_uhttps://libcatalog.cimmyt.org/Download/cis/59836.pdf _yAccess only for CIMMYT Staff
942			_cJA _n0 _2ddc