000			03239nab a22004217a 4500
999			_c58536 _d58528
001			58536
003			MX-TxCIM
005			20250714162103.0
008			150723s2017 xxu|||po p||| 00| 0 eng d
024	8		_ahttps://doi.org/10.1371/journal. pgen.1006666
040			_aMX-TxCIM
041			_aeng
100	1		_94644 _aBrandenburg, J.T.
245	1	0	_aIndependent introductions and admixtures have contributed to adaptation of European maize and its American counterparts _h[Electronic Resource]
260			_aSan Francisco, USA : _bPublic Library of Science, _c2017.
500			_aOpen Access
500			_aPeer review
520			_aThrough the local selection of landraces, humans have guided the adaptation of crops to a vast range of climatic and ecological conditions. This is particularly true of maize, which was domesticated in a restricted area of Mexico but now displays one of the broadest cultivated ranges worldwide. Here, we sequenced 67 genomes with an average sequencing depth of 18x to document routes of introduction, admixture and selective history of European maize and its American counterparts. To avoid the confounding effects of recent breeding, we targeted germplasm (lines) directly derived from landraces. Among our lines, we discovered 22,294,769 SNPs and between 0.9% to 4.1% residual heterozygosity. Using a segmentation method, we identified 6,978 segments of unexpectedly high rate of heterozygosity. These segments point to genes potentially involved in inbreeding depression, and to a lesser extent to the presence of structural variants. Genetic structuring and inferences of historical splits revealed 5 genetic groups and two independent European introductions, with modest bottleneck signatures. Our results further revealed admixtures between distinct sources that have contributed to the establishment of 3 groups at intermediate latitudes in North America and Europe. We combined differentiation- and diversity-based statistics to identify both genes and gene networks displaying strong signals of selection. These include genes/gene networks involved in flowering time, drought and cold tolerance, plant defense and starch properties. Overall, our results provide novel insights into the evolutionary history of European maize and highlight a major role of admixture in environmental adaptation, paralleling recent findings in humans.
546			_aText in English
650		7	_aMaize _gAGROVOC _2 _91173
650		7	_91132 _aGenomics _2AGROVOC
650		7	_91134 _aGenotypes _2AGROVOC
650		7	_99025 _aPlant Genetics _2AGROVOC
651		7	_94645 _aEurope _2AGROVOC
651		7	_94646 _aAmericas _2AGROVOC
700	0		_94647 _aTristan Mary-Huard
700	1		_94648 _aRigaill, G.
700	1		_aHearne, S. _gGenetic Resources Program _gDirector General's Office _8INT3287 _9912
700	1		_94649 _aCorti, H.
700	1		_94650 _aJoets, J.
700	1		_94651 _aVitte, C.
700	1		_94628 _aCharcosset, A.
700	1		_94652 _aNicolas, S.D.
700	1		_94653 _aTenaillon, M.I.
773	0		_dSan Francisco, CA (USA) : Public Library of Science _tPLoS Genetics _gv. 13, no. 3 : e1006666
856	4		_yOpen Access through DSpace _uhttps://hdl.handle.net/10883/18268
942			_2ddc _cJA _n0