000 03495nab a22004817a 4500
999 _c57013
_d57005
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005 20211007202235.0
008 150903b -uk|||p|op||| 00| 0 eng d
024 8 _ahttps://doi.org/10.1186/s12870-015-0589-z
040 _aMX-TxCIM
041 _aeng
100 2 _91411
_aJunqiang Ding
245 1 0 _aGenome-wide association mapping reveals novel sources of resistance to northern corn leaf blight in maize
260 _aLondon (United Kingdom) :
_b BioMed Central Ltd,
_c2015.
500 _aOpen Access
500 _aPeer review
520 _aBackground: Northern corn leaf blight (NCLB) caused by Exserohilum turcicum is a destructive disease in maize. Using host resistance to minimize the detrimental effects of NCLB on maize productivity is the most cost-effective and appealing disease management strategy. However, this requires the identification and use of stable resistance genes that are effective across different environments. Results: We evaluated a diverse maize population comprised of 999 inbred lines across different environments for resistance to NCLB. To identify genomic regions associated with NCLB resistance in maize, a genome-wide association analysis was conducted using 56,110 single-nucleotide polymorphism markers. Single-marker and haplotype-based associations, as well as Anderson-Darling tests, identified alleles significantly associated with NCLB resistance. The single-marker and haplotype-based association mappings identified twelve and ten loci (genes), respectively, that were significantly associated with resistance to NCLB. Additionally, by dividing the population into three subgroups and performing Anderson-Darling tests, eighty one genes were detected, and twelve of them were related to plant defense. Identical defense genes were identified using the three analyses. Conclusion: An association panel including 999 diverse lines was evaluated for resistance to NCLB in multiple environments, and a large number of resistant lines were identified and can be used as reliable resistance resource in maize breeding program. Genome-wide association study reveals that NCLB resistance is a complex trait which is under the control of many minor genes with relatively low effects. Pyramiding these genes in the same background is likely to result in stable resistance to NCLB.
536 _aGenetic Resources Program
536 _aGlobal Maize Program
546 _aText in english
591 _bCIMMYT Informa No. 1951
594 _aCLIH01
594 _aINT2822
594 _aINT2714
594 _aINT2765
650 7 _aGenomes
_gAGROVOC
_2
_91131
650 1 0 _91512
_aAssociation mapping
650 7 _aMaize
_gAGROVOC
_2
_91173
650 7 _91937
_aNucleotide sequence
_2AGROVOC
700 0 _91728
_aFarhan Ali
700 0 _91729
_aGengshen Chen
700 0 _91363
_aNing Yang
700 1 _9398
_aJianbing Yan
700 1 _9764
_aHuihui Li
_gGenetic Resources Program
_8CLIH01
700 1 _91730
_aNarro, L.
_gGlobal Maize Program
_gIntegrated Development Program
_8INT2062
700 1 _aMagorokosho, C.
_gFormerly Global Maize Program
_8INT2714
_9854
700 1 _9858
_aMakumbi, D.
_gGlobal Maize Program
_8INT2765
700 1 _9861
_aMahuku, G.
_gGlobal Maize Program
_8INT2822
773 0 _wu79387
_x1471-2229
_dLondon (United Kingdom) : BioMed Central Ltd
_tBMC Plant Biology
_gv. 15, p. 206
856 4 _yOpen Access through DSpace
_uhttp://hdl.handle.net/10883/4514
942 _2ddc
_cJA
_n0