000			02696nam a22003497a 4500
001			G54693
003			MX-TxCIM
005			20250630105413.0
008			250630s1993||||-us||||| |||| 00| 0 eng d
040			_aMX-TxCIM
041			_aeng
043			_aUS
072		0	_aF30
072		0	_aU10
090			_aLook under author name
100	1		_aDoerge, R.W.
245	1	0	_aStatistical methods for locating quantitative trait loci with molecular markers
260			_aRaleigh, NC (USA): _bNorth Carolina State University, _c1993
300			_axviii, 158 pages
340			_aPrinted
500			_aThesis (Ph. D)
520			_aRecent progress in molecular genetics has made it possible for scientists to gain a fine scale genetic map of various organisms. Such improvements in molecular genetics have been attained by placing genetic markers (RFLPs, isozymes, RAPDs) along a genome of interest. It is through these markers that an initial framework for inferences about quantitative trait loci (QTL) can be built. Quantitative traits are largely affected by an association of many genes, therefore the location which involves these quantitative traits cannot be described simply in the context of a typical genetic map scenario. Instead, a statistical representation of the quantitative trait serves to tell us how much of the genetic variation in the parental lines is contributed to the offspring by each region that is identified through genetic markers in the progeny. Statistical issues leading up to and including the search and location of quantitative trait loci are investigated. A preliminary method for ordering molecular markers is presented with the purpose of providing the fundamental structure involved in the search for QTL. In developing this method, issues of genetic maps, recombination, and assumptions of the mating scheme are investigated. The statistical theory supporting single marker and interval mapping methods for detecting and locating QTL is explored for the purpose of evaluating the robustness of these procedures. Lastly, a new method for detecting and locating QTL is described. Once QTL have been identified as being contained within a specific region of DNA this will allow for eventual molecular cloning and characterization of genes involved in quantitative inheritance.
546			_aEnglish
595			_aTC
650		7	_91848 _aGenetic markers _2AGROVOC
650		7	_aQuantitative Trait Loci _91853 _2AGROVOC
650		7	_aRestriction fragment length polymorphism _96122 _2AGROVOC
650		7	_aGenetic maps _94190 _2AGROVOC
650		7	_aGenetic variation _2AGROVOC _91129
650		7	_aStatistical analysis _91276 _2AGROVOC
942			_cTH _2ddc
999			_c38850 _d38850