000			01971nab a22003377a 4500
001			G99705
003			MX-TxCIM
005			20190717180628.0
008			121211b |||p||p||||||| |z||| |
022	0		_a1367-4803
024	8		_ahttps://doi.org/10.1093/bioinformatics/btu206
040			_aMX-TxCIM
041	0		_aEn
100	1		_aHickey, J.M. _92447
245	0	0	_aAlphaMPSim: _b flexible simulation of multi-parent crosses
260			_c2014
500			_aPeer-review: Yes - Open Access: Yes | http://ip-science.thomsonreuters.com/cgi-bin/jrnlst/jlresults.cgi?PC=MASTER&ISSN=1367-4803
500			_aReference only
520			_aMulti-parent crosses of recombinant inbred lines (RILs) exist in many species for fine-scale analysis of genome structure and marker-trait association. These populations encompass a wide range of crossing designs with varying potential. AlphaMPSim is a flexible simulation program that is efficiently designed for comparison of alternative designs for traits with varying genetic architectures and biallelic markers with densities up to full sequence. A large pool of founder haplotypes can be supplied by the user, or generated via integration with external coalescent simulation programs such as MaCS. From these, diverse founders for multi-parent designs can be generated automatically, and users can compare designs generated from diverse pedigrees. Full tracking of identity by descent (IBD) status of alleles within the pedigree is undertaken and output files are compatible with commonly available analysis packages in R.
536			_aGenetic Resources Program
546			_aEnglish
591			_aCIMMYT Informa 2015|Oxford
593			_aCarelia Juarez
594			_aINT3287
595			_aCSC
700	1		_92444 _aGorjanc, G.
700	1		_aHuang, B.E., _ecoaut.
700	1		_9912 _aHearne, S. _gGenetic Resources Program _8INT3287
773	0		_tBioinformatics _gv. 30, no. 18, p. 2686-2688
942			_cJA
999			_c30944 _d30944