| 000 | 02662nab a22003617a 4500 | ||
|---|---|---|---|
| 001 | G98309 | ||
| 003 | MX-TxCIM | ||
| 005 | 20211124173450.0 | ||
| 008 | 211124s2013 xxk|||p|op||| 00| 0 eng d | ||
| 022 | _a1365-2540 (Online) | ||
| 022 | _a0018-067X | ||
| 024 | 8 | _ahttps://doi.org/10.1038/hdy.2013.24 | |
| 040 | _aMX-TxCIM | ||
| 041 | _aeng | ||
| 090 | _aCIS-7404 | ||
| 100 | 1 |
_9948 _aCharles Chen _gGenetic Resources Program _8INT3383 |
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| 245 | 1 | 0 | _aLineage-specific mapping of quantitative trait loci |
| 260 |
_aUnited Kingdom : _bNature Publishing Group, _c2013. |
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| 500 | _aPeer review | ||
| 500 | _aPeer-review: Yes - Open Access: Yes|http://science.thomsonreuters.com/cgi-bin/jrnlst/jlresults.cgi?PC=MASTER&ISSN=0018-067X | ||
| 520 | _aWe present an approach for quantitative trait locus (QTL) mapping, termed as ‘lineage-specific QTL mapping’, for inferring allelic changes of QTL evolution along with branches in a phylogeny. We describe and analyze the simplest case: by adding a third taxon into the normal procedure of QTL mapping between pairs of taxa, such inferences can be made along lineages to a presumed common ancestor. Although comparisons of QTL maps among species can identify homology of QTLs by apparent co-location, lineage-specific mapping of QTL can classify homology into (1) orthology (shared origin of QTL) versus (2) paralogy (independent origin of QTL within resolution of map distance). In this light, we present a graphical method that identifies six modes of QTL evolution in a three taxon comparison. We then apply our model to map lineage-specific QTLs for inbreeding among three taxa of yellow monkey-flower: Mimulus guttatus and two inbreeders M. platycalyx and M. micranthus, but critically assuming outcrossing was the ancestral state. The two most common modes of homology across traits were orthologous (shared ancestry of mutation for QTL alleles). The outbreeder M. guttatus had the fewest lineage-specific QTL, in accordance with the presumed ancestry of outbreeding. Extensions of lineage-specific QTL mapping to other types of data and crosses, and to inference of ancestral QTL state, are discussed. | ||
| 536 | _aGenetic Resources Program | ||
| 546 | _aText in English | ||
| 594 | _aINT3383 | ||
| 595 | _aCSC | ||
| 650 | 1 | 0 | _aevolution of mating systems |
| 650 | 1 | 0 | _aMimulus |
| 650 | 1 | 0 |
_aQuantitative trait locus mapping _91392 |
| 700 | 1 |
_aRitland, K. _925277 |
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| 773 | 0 |
_tHeredity _gv. 111, p. 106-113 _x0018-067X _wG444336 _dUnited Kingdom : Nature Publishing Group, 2013. |
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| 856 | 4 |
_uhttps://hdl.handle.net/20.500.12665/354 _yAccess only for CIMMYT Staff |
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| 942 |
_cJA _2ddc _n0 |
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_c30264 _d30264 |
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