000			01559nab a22002777a 4500
001			G48127
003			MX-TxCIM
005			20170719154952.0
008			121211b |||p||p||||||| |z||| |
022	0		_a0016-6723
040			_aMX-TxCIM
041	0		_aEn
043			_aXE
072		0	_aL10
082	0	4	_a75-023305
100	1		_aBulmer, M.G. _9453
245	0	0	_aLinkage disequilibrium and genetic variability
260			_c1974
340			_aPrinted
520			_aIt has been shown previously that, even in the absence of linkage, selection can cause an appreciable change in the genetic variance of a metric character due to disequilibrium; this change is temporary and is rapidly reversed when selection ceases. This result is here extended to allow for the effect of linkage, and it is shown that the change in the variance is effectively determined by the harmonic mean of the recombination fractions. The validity of the approximate general formula derived here has been checked by comparison with exact results obtained from models with five or six loci. In order to determine the likely value of the harmonic mean recombination fraction, a simple model was constructed in which it was assumed that loci are distributed at random along the chromosome maps. Results of computer simulations of this model are reported for different chromosome numbers and numbers of loci.
546			_aEnglish
591			_aCOMOD
650	1	0	_aAnimal genetics and breeding
773	0		_tGenetical Research _n75-023305 _gv. 23, no. 3, p. 281-289
942			_cJA _2ddc
999			_c12921 _d12921