TY  - JA
AU  - Kaur,H.
AU  - Sharma,P.
AU  - Kumar,J.
AU  - Singh,V.K.
AU  - Vasistha,N.K.
AU  - Vijay Gahlaut
AU  - Tyagi,V.
AU  - Verma,S.K.
AU  - Sukhwinder-Singh
AU  - Dhaliwal,H.S.
AU  - Sheikh,I.
TI  - Genetic analysis of iron, zinc and grain yield in wheat-Aegilops derivatives using multi-locus GWAS
SN  - 0301-4851
PY  - 2023///
CY  - Dordrecht (Netherlands)
PB  - Springer Netherlands, 
KW  - Aegilops
KW  - AGROVOC
KW  - Genotyping-by-sequencing
KW  - Genome-wide association studies
KW  - Iron
KW  - Wheat
KW  - Zinc
N1  - Peer review
N2  - Background: Wheat is a major staple crop and helps to reduce worldwide micronutrient deficiency. Investigating the genetics that control the concentrations of iron (Fe) and zinc (Zn) in wheat is crucial. Hence, we undertook a comprehensive study aimed at elucidating the genomic regions linked to the contents of Fe and Zn in the grain. Methods and results: We performed the multi-locus genome-wide association (ML-GWAS) using a panel of 161 wheat-Aegilops substitution and addition lines to dissect the genomic regions controlling grain iron (GFeC), and grain zinc (GZnC) contents. The wheat panel was genotyped using 10,825 high-quality SNPs and phenotyped in three different environments (E1-E3) during 2017–2019. A total of 111 marker-trait associations (MTAs) (at p-value < 0.001) were detected that belong to all three sub-genomes of wheat. The highest number of MTAs were identified for GFeC (58), followed by GZnC (44) and yield (9). Further, six stable MTAs were identified for these three traits and also two pleiotropic MTAs were identified for GFeC and GZnC. A total of 1291 putative candidate genes (CGs) were also identified for all three traits. These CGs encode a diverse set of proteins, including heavy metal-associated (HMA), bZIP family protein, AP2/ERF, and protein previously associated with GFeC, GZnC, and grain yield. Conclusions: The significant MTAs and CGs pinpointed in this current study are poised to play a pivotal role in enhancing both the nutritional quality and yield of wheat, utilizing marker-assisted selection (MAS) techniques
T2  - Molecular Biology Reports
DO  - https://doi.org/10.1007/s11033-023-08800-y
ER  -