TY  - JA
AU  - Feldmann,M.J.
AU  - Covarrubias-Pazaran,G.
AU  - Piepho,H.P.
TI  - Complex traits and candidate genes : : estimation of genetic variance components across multiple genetic architectures
SN  - 2160-1836
PY  - 2023///
CY  - Bethesda, MD (USA)
PB  - Genetics Society of America, 
KW  - Mendelism
KW  - AGROVOC
KW  - Genetic variance
KW  - Genome-wide association studies
KW  - Phenotypes
KW  - Chromosome mapping
N1  - Peer review; Open Access
N2  - Large-effect loci—those statistically significant loci discovered by genome-wide association studies or linkage mapping—associated with key traits segregate amidst a background of minor, often undetectable, genetic effects in wild and domesticated plants and animals. Accurately attributing mean differences and variance explained to the correct components in the linear mixed model analysis is vital for selecting superior progeny and parents in plant and animal breeding, gene therapy, and medical genetics in humans. Marker-assisted prediction and its successor, genomic prediction, have many advantages for selecting superior individuals and understanding disease risk. However, these two approaches are less often integrated to study complex traits with different genetic architectures. This simulation study demonstrates that the average semivariance can be applied to models incorporating Mendelian, oligogenic, and polygenic terms simultaneously and yields accurate estimates of the variance explained for all relevant variables. Our previous research focused on large-effect loci and polygenic variance separately. This work aims to synthesize and expand the average semivariance framework to various genetic architectures and the corresponding mixed models. This framework independently accounts for the effects of large-effect loci and the polygenic genetic background and is universally applicable to genetics studies in humans, plants, animals, and microbes
UR  - https://hdl.handle.net/10883/22707
T2  - G3: Genes, Genomes, Genetics
DO  - https://doi.org/10.1093/g3journal/jkad148
ER  -