TY  - JA
AU  - Biswal,A.K.
AU  - Alakonya,A.
AU  - Mottaleb,K.A.
AU  - Hearne,S.
AU  - Sonder,K.
AU  - Molnar,T.L.
AU  - Jones,A.M.
AU  - Pixley,K.V.
AU  - Prasanna,B.M.
TI  - Maize Lethal Necrosis disease : : review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa
SN  - 1471-2229
PY  - 2022///
CY  - London (United Kingdom)
PB  - BioMed Central, 
KW  - Drought stress
KW  - AGROVOC
KW  - Gene editing
KW  - Maize
KW  - Necrosis
KW  - Potyvirus
KW  - Quantitative Trait Loci
KW  - Africa South of Sahara
N1  - Peer review; Open Access
N2  - Background: Maize lethal necrosis (MLN) disease is a significant constraint for maize producers in sub-Saharan Africa (SSA). The disease decimates the maize crop, in some cases, causing total crop failure with far-reaching impacts on regional food security. Results: In this review, we analyze the impacts of MLN in Africa, finding that resource-poor farmers and consumers are the most vulnerable populations. We examine the molecular mechanism of MLN virus transmission, role of vectors and host plant resistance identifying a range of potential opportunities for genetic and phytosanitary interventions to control MLN. We discuss the likely exacerbating effects of climate change on the MLN menace and describe a sobering example of negative genetic association between tolerance to heat/drought and susceptibility to viral infection. We also review role of microRNAs in host plant response to MLN causing viruses as well as heat/drought stress that can be carefully engineered to develop resistant varieties using novel molecular techniques. Conclusions: With the dual drivers of increased crop loss due to MLN and increased demand of maize for food, the development and deployment of simple and safe technologies, like resistant cultivars developed through accelerated breeding or emerging gene editing technologies, will have substantial positive impact on livelihoods in the region. We have summarized the available genetic resources and identified a few large-effect QTLs that can be further exploited to accelerate conversion of existing farmer-preferred varieties into resistant cultivars
UR  - https://hdl.handle.net/10883/22293
DO  - https://doi.org/10.1186/s12870-022-03932-y
T2  - BMC Plant Biology
ER  -