TY  - JA
AU  - Fei He
AU  - Wei Wang
AU  - Rutter,W.B.
AU  - Jordan,K.
AU  - Jie Ren
AU  - Taagen,E.
AU  - DeWitt,N.
AU  - Sehgal,D.
AU  - Sukumaran,S.
AU  - Dreisigacker,S.
AU  - Reynolds,M.P.
AU  - Halder,J.
AU  - Sehgal,S.K.
AU  - Shuyu Liu
AU  - Jianli Chen
AU  - Fritz,A.K.
AU  - Cook,J.
AU  - Brown-Guedira,G.
AU  - Pumphrey,M.
AU  - Carter,A.
AU  - Sorrells,M.E.
AU  - Dubcovsky,J.
AU  - Hayden,M.
AU  - Akhunova,A.
AU  - Morrell,P.L.
AU  - Szabo,L.J.
AU  - Rouse,M.N.
AU  - Akhunov,E.
TI  - Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat
SN  - 2041-1723
PY  - 2022///
CY  - London (United Kingdom)
PB  - Nature Publishing Group, 
KW  - Agronomic characters
KW  - AGROVOC
KW  - Gene Expression
KW  - Polyploidy
KW  - Wheat
N1  - Peer review; Open Access
N2  - Allopolyploidy greatly expands the range of possible regulatory interactions among functionally redundant homoeologous genes. However, connection between the emerging regulatory complexity and expression and phenotypic diversity in polyploid crops remains elusive. Here, we use diverse wheat accessions to map expression quantitative trait loci (eQTL) and evaluate their effects on the population-scale variation in homoeolog expression dosage. The relative contribution of cis- and trans-eQTL to homoeolog expression variation is strongly affected by both selection and demographic events. Though trans-acting effects play major role in expression regulation, the expression dosage of homoeologs is largely influenced by cis-acting variants, which appear to be subjected to selection. The frequency and expression of homoeologous gene alleles showing strong expression dosage bias are predictive of variation in yield-related traits, and have likely been impacted by breeding for increased productivity. Our study highlights the importance of genomic variants affecting homoeolog expression dosage in shaping agronomic phenotypes and points at their potential utility for improving yield in polyploid crops
UR  - https://hdl.handle.net/10883/21992
DO  - https://doi.org/10.1038/s41467-022-28453-y
T2  - Nature communications
ER  -