TY  - JA
AU  - Sehgal,D.
AU  - Rosyara,U.
AU  - Mondal,S.
AU  - Singh,R.P.
AU  - Poland,J.A.
AU  - Dreisigacker,S.
TI  - Incorporating genome-wide association mapping results into genomic prediction models for grain yield and yield stability in CIMMYT spring bread wheat
SN  - 1664-462X
PY  - 2020///
CY  - Switzerland
PB  - Frontiers
KW  - AGROVOC
KW  - Triticum aestivum
KW  - Genomes
KW  - Marker-assisted selection
KW  - Genomics
N1  - Peer review; Open Access; WC; FP3
N2  - Untangling the genetic architecture of grain yield (GY) and yield stability is an important determining factor to optimize genomics-assisted selection strategies in wheat. We conducted in-depth investigation on the above using a large set of advanced bread wheat lines (4,302), which were genotyped with genotyping-by-sequencing markers and phenotyped under contrasting (irrigated and stress) environments. Haplotypes-based genome-wide-association study (GWAS) identified 58 associations with GY and 15 with superiority index Pi (measure of stability). Sixteen associations with GY were “environment-specific” with two on chromosomes 3B and 6B with the large effects and 8 associations were consistent across environments and trials. For Pi, 8 associations were from chromosomes 4B and 7B, indicating ‘hot spot’ regions for stability. Epistatic interactions contributed to an additional 5–9% variation on average. We further explored whether integrating consistent and robust associations identified in GWAS as fixed effects in prediction models improves prediction accuracy. For GY, the model accounting for the haplotype-based GWAS loci as fixed effects led to up to 9–10% increase in prediction accuracy, whereas for Pi this approach did not provide any advantage. This is the first report of integrating genetic architecture of GY and yield stability into prediction models in wheat
UR  - https://hdl.handle.net/10883/21102
T2  - Frontiers in Plant Science
DO  - https://doi.org/10.3389/fpls.2020.00197
ER  -