TY  - JA
AU  - Jie Chen
AU  - Xin Hu
AU  - Taotao Shi
AU  - Huanran Yin
AU  - Dongfa Sun
AU  - Yuanfeng Hao
AU  - Xianchun Xia
AU  - Jie Luo
AU  - Fernie,A.R.
AU  - He Zhonghu
AU  - Wei Chen
TI  - Metabolite‐based genome‐wide association study enables dissection of the flavonoid decoration pathway of wheat kernels
SN  - 1467-7644
PY  - 2020///
CY  - Oxford (United Kingdom)
PB  - Wiley
KW  - AGROVOC
KW  - Flavonoids
KW  - Metabolites
KW  - Wheat
KW  - Kernels
N1  - Peer review; Open Access; WC
N2  - The marriage of metabolomic approaches with genetic design has proven a powerful tool in dissecting diversity in the metabolome and has additionally enhanced our understanding of complex traits. That said, such studies have rarely been carried out in wheat. In this study, we detected 805 metabolites from wheat kernels and profiled their relative contents among 182 wheat accessions, conducting a metabolite‐based genome‐wide association study (mGWAS) utilizing 14 646 previously described polymorphic SNP markers. A total of 1098 mGWAS associations were detected with large effects, within which 26 candidate genes were tentatively designated for 42 loci. Enzymatic assay of two candidates indicated they could catalyse glucosylation and subsequent malonylation of various flavonoids and thereby the major flavonoid decoration pathway of wheat kernel was dissected. Moreover, numerous high‐confidence genes associated with metabolite contents have been provided, as well as more subdivided metabolite networks which are yet to be explored within our data. These combined efforts presented the first step towards realizing metabolomics‐associated breeding of wheat
UR  - https://hdl.handle.net/10883/20943
T2  - Plant Biotechnology Journal
DO  - https://doi.org/10.1111/pbi.13335
ER  -