TY  - JA
AU  - Horton,M.W.
AU  - Hancock,A.M.
AU  - Yu S. Huang
AU  - Toomajian,C.
AU  - Atwell,S.
AU  - Auton,A.
AU  - Muliyati,N.W.
AU  - Platt,A.
AU  - Sperone,F.G.
AU  - Vilhjálmsson,B.J.
AU  - Nordborg,M.
AU  - Borevitz,J.O.
AU  - Bergelson,J.
TI  - Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegMap panel
SN  - 1546-1718
PY  - 2012///
CY  - United Kingdom
PB  - Nature Publishing Group
KW  - Arabidopsis thaliana
KW  - AGROVOC
KW  - Genetic variation
KW  - Genomics
N1  - Peer review
N2  - Arabidopsis thaliana is native to Eurasia and is naturalized across the world. Its ability to be easily propagated and its high phenotypic variability make it an ideal model system for functional, ecological and evolutionary genetics. To date, analyses of the natural genetic variation of A. thaliana have involved small numbers of individual plants or genetic markers. Here we genotype 1,307 worldwide accessions, including several regional samples, using a 250K SNP chip. This allowed us to produce a high-resolution description of the global pattern of genetic variation. We applied three complementary selection tests and identified new targets of selection. Further, we characterized the pattern of historical recombination in A. thaliana and observed an enrichment of hotspots in its intergenic regions and repetitive DNA, which is consistent with the pattern that is observed for humans but which is strikingly different from that observed in other plant species. We have made the seeds we used to produce this Regional Mapping (RegMap) panel publicly available. This panel comprises one of the largest genomic mapping resources currently available for global natural isolates of a non-human species
T2  - Nature Genetics
DO  - https://doi.org/10.1038/ng.1042
ER  -