TY  - JA
AU  - Helaly,S.E.
AU  - Ashrafi,S.
AU  - Teponno,R.B.
AU  - Bernecker,S.
AU  - Dababat,A.A.
AU  - Maier,W.
AU  - Stadler,M.
TI  - Nematicidal cyclic lipodepsipeptides and a xanthocillin derivative from a phaeosphariaceous fungus parasitizing eggs of the plant parasitic nematode Heterodera filipjevi
PY  - 2018///.
CY  - Ohio, U.S. : 
PB  - American Chemical Society, 
KW  - AGROVOC
KW  - Disease control
KW  - Plant nematodes
KW  - Heterodera
N1  - Peer review
N2  - The new cyclic lipodepsipeptide ophiotine (1), two new arthrichitin derivatives named arthrichitins B (4) and C (5), a new xanthocillin-like alkaloid, xanthomide Z (2), and the previously described arthrichitin (3) were isolated from the liquid culture broth of a nematode-associated fungus with affinities to the genus Ophiosphaerella. The structural elucidation and determination of the absolute configuration of the new molecules were accomplished using a combination of spectroscopic and chemical techniques, including 1D and 2D NMR, HRMS, and Marfey's analysis. Opiotine (1) displayed moderate nematicidal activity against the host nematode (Heterodera filipjevi), while xanthomide Z (2) exhibited very weak activity. Arthrichitin C (5) showed very weak cytotoxic effects on several cancer cell lines, with IC50 values in the range of 24-33 ?M. Xanthomide Z is among few xanthocillin derivatives that comprise formamide functions instead of the cyano functions that are usually observed in this class of fungal alkaloids
UR  - https://libcatalog.cimmyt.org/Download/cis/59836.pdf
DO  - https://doi.org/10.1021/acs.jnatprod.8b00486
T2  - Journal of Natural Products
ER  -