TY  - JA
AU  - Guzman de Peña,D.
AU  - Ruiz-Herrera,J.
TI  - Relationship between Aflatoxin Biosynthesis and Sporulation in Aspergillus parasiticus
SN  - 1087-1845
PY  - 1997///
KW  - Aflatoxins
KW  - Aspergillus parasiticus
KW  - Asporogenous mutants
KW  - Diaminobutanone
KW  - Sporulation
N2  - Regulation of aflatoxin biosynthesis during differentiation ofAspergillus parasiticuswas analyzed by using a drug that inhibits the development of the fungus and mutants affected in sporulation. Diaminobutanone, a competitive inhibitor of ornithine decarboxylase, repressed spore germination. If added after spore germination had occurred, it blocked sporulation completely and suppressed aflatoxin biosynthesis, but was only partially inhibitory of mycelial growth. Putrescine partially counteracted the inhibitory effect of the drug on both sporulation and aflatoxin biosynthesis. Analysis of mutants affected in sporulation confirmed the existence of a relationship between sporulation and aflatoxin formation. A nonsporulating mutant was unable to synthesize aflatoxins. In a sectorial mutant, the sporulating sector synthesized aflatoxins normally, whereas the asporogenous sector was unable to do so. It is suggested that regulation of aflatoxin biosynthesis is correlated with the sporulation process
T2  - Fungal Genetics and Biology
ER  -