TY  - JA
AU  - Huihui Li
AU  - Luyan Zhang
AU  - Jiankang Wang
TI  - Analysis and answers to frequently asked questions in quantitative trait locus mapping
SN  - 0496-3490
PY  - 2010///
CY  - Beijing (China)
PB  - Science Press
KW  - Quantitative Trait Loci
KW  - AGROVOC
KW  - Chromosome mapping
KW  - Statistical methods
N1  - Peer-review: No - Open Access: Yes|http://211.155.251.148:8080/zwxb/EN/column/column81.shtml; Peer review; Open Access; Abstract in Chinese and English
N2  - QTL mapping is an important step in gene fine mapping, map-based cloning, and the efficient use of gene information in molecular breeding. Questions are frequently met and asked in the application of QTL mapping in practical genetic populations. Questions related to statistical method of QTL mapping are: what does LOD score mean? What is the relationship between the reliability of detected QTL and the LOD threshold? How to evaluate different QTL mapping methods? How to improve the QTL detection power? Questions related to genetic parameter estimation are: how to calculate the phenotypic variance explained by each detected QTL? How to determine the source of favorable alleles at detected QTL? How efficient is the selective genotyping? Can composite traits be used in QTL mapping? Questions related to linkage map and mapping populations are: does the phenotype of a trait in interest have to follow a normal distribution? Does the increase in marker density greatly improve QTL mapping power? What effects will missing markers have in QTL mapping? What effects will segregation distortion have in QTL mapping? Our objective in this paper was to give an analysis and answer to each of the 12 frequently asked questions, based on our studies in past several years
UR  - http://hdl.handle.net/10883/1827
DO  - https://doi.org/10.3724/SP.J.1006.2010.00918
T2  - Acta Agronomica Sinica
ER  -