Association analysis in structured plant populations, an adaptive mixed LASSO approach (Record no. 8011)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02553nam a22003017a 4500 |
| 001 - CONTROL NUMBER | |
| control field | G94606 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240919020942.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 121211s ||||f| 0 p|p||0|| | |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MX-TxCIM |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) | |
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) | CIS-6161 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dong Wang |
| Affiliation | Plant and Animal Genomes Conference, XVIII; San Diego, CA (USA); 9-13 Jan 2010. Abstracts of oral and poster presentations |
| 245 00 - TITLE STATEMENT | |
| Title | Association analysis in structured plant populations, an adaptive mixed LASSO approach |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2010 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 page |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Recently, there has been heightened interest in performing association analysis in important crop species. The development of mixed linear models for plant association mapping has significantly advanced the statistical methodology in this field. However, the mixed linear model has been mostly limited to single marker analysis. On the other hand, the lack of knowledge on epistasis and GxE interactions has become one of the major impediments of utilizing genomic information for crop improvement. We report the development of the adaptive mixed LASSO method that can incorporate a large number of predictors while simultaneously accounting for the population structure. LASSO can deal with situations where the number of explanatory variables is much larger than the sample size, which is not feasible for traditional regression methods. By extending adaptive LASSO to include random effects for structured populations, we can readily apply our method to the setting of plant association mapping. Our results show that the adaptive mixed LASSO method is very promising in modeling multiple genetic effects (main QTL effects and epistasis) as well as modeling gene by environment interactions when a large number of markers are available and the population structure cannot be ignored. Since no equivalent method has been proposed in the setting of crop association analysis, it is expected to have a significant impact on the study of complex traits in important crop species. Applications to wheat breeding programs has been planned with the potential of influencing plant breeding practices. |
| 536 ## - FUNDING INFORMATION NOTE | |
| Text of note | Genetic Resources Program |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 594 ## - STAFFID | |
| StaffID | INT2542|CCJL01 |
| 595 ## - COLLECTION | |
| Collection | CIMMYT Staff Publications Collection |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Baenziger, S.P., |
| Relator term | coaut. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dweikat, I., |
| Relator term | coaut. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eskridge, K.M., |
| Relator term | coaut. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 842 |
| Personal name | Jiankang Wang |
| Miscellaneous information | Genetic Resources Program |
| Field link and sequence number | INT2542 |
| Relator term | coaut. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Crossa, J. |
| Miscellaneous information | Genetic Resources Program |
| Field link and sequence number | CCJL01 |
| 9 (RLIN) | 59 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Conference proceedings |
| Date last seen | Total Checkouts | Full call number | Price effective from | Koha item type | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Withdrawn status | Home library | Current library | Date acquired |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 07/19/2017 | CIS-6161 | 07/19/2017 | Conference proceedings | Not Lost | Dewey Decimal Classification | CIMMYT Staff Publications Collection | CIMMYT Knowledge Center: John Woolston Library | CIMMYT Knowledge Center: John Woolston Library | 07/19/2017 |