Integrated genome-wide association study (GWAS) and metabolomics identify genetic and metabolic drivers of stripe rust resistance in wheat from the Western Himalayas (Record no. 69760)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03861nab|a22005297a|4500 |
| 001 - CONTROL NUMBER | |
| control field | 69760 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260119163000.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 20261s2026|||||gw ||p|op||||00||0|eng|dd |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1438-793X |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1438-7948 (Online) |
| 024 8# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | https://doi.org/10.1007/s10142-025-01799-4 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MX-TxCIM |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Farkhandah Jan |
| 9 (RLIN) | 41105 |
| 245 10 - TITLE STATEMENT | |
| Title | Integrated genome-wide association study (GWAS) and metabolomics identify genetic and metabolic drivers of stripe rust resistance in wheat from the Western Himalayas |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Germany : |
| Name of publisher, distributor, etc. | Springer, |
| Date of publication, distribution, etc. | 2026. |
| 500 ## - GENERAL NOTE | |
| General note | Peer review |
| 500 ## - GENERAL NOTE | |
| General note | Reference Only |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Wheat production is increasingly threatened by biotic and abiotic stresses, with stripe rust, caused by Puccinia striiformis f. sp. tritici being among the most devastating diseases. To dissect stripe rust resistance mechanisms, 329 diverse wheat genotypes were evaluated across six distinct environments in India (three locations over two years). The panel exhibited wide variation for stripe rust resistance and was genotyped using a 35K SNP-array. Genome-wide association study (GWAS) revealed 49 significant marker-trait associations (MTAs), explaining 1.58% to 29.7% of phenotypic variation, with notable quantitative-trait locus (QTL) hotspots on chromosomes 2A, 3B and 4B. Several MTAs co-localized with known resistance loci, while AX-92621629 appeared novel, suggesting new genomic region contributing to adult plant resistance. Candidate genes near significant single-nucleotide polymorphisms (SNPs) were enriched for defense-related functions, including nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins, receptor-like kinases and transcription factors involved in defense signaling. To further investigate resistance mechanisms, metabolomic profiling, phytohormone and flavonoid dynamics were conducted on two contrasting wheat genotypes (resistant SKUA_415; susceptible SKUA_246) using untargeted Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) approaches. Key defense-related metabolites, including myo-inositol, ketoglutaric acid, rutin and schaftoside and kaempferol derivatives were identified. These metabolites were downregulated in SKUA_246 following infection, while SKUA_415 showed up-regulation of defense phytohormones, anthocyanins and flavonoids. The two contrasting genotypes also exhibited clear allelic differentiation at key resistance-linked SNP loci, consistent with their divergent metabolomic responses. This study highlights identification of promising genes/QTLs/MTAs and metabolic markers for breeding next-generation stripe rust resistant wheat cultivars. |
| 546 ## - LANGUAGE NOTE | |
| Language note | Text in English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Wheat |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 1310 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Stripe rust |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 1666 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Genome-wide association studies |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 31443 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Quantitative Trait Loci |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 1853 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Single nucleotide polymorphisms |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 10805 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Metabolomics |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 30115 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Parthiban, M. |
| 9 (RLIN) | 29500 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sofora Jan |
| 9 (RLIN) | 41106 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pradhan, A.K. |
| 9 (RLIN) | 16709 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kumar, S. |
| 9 (RLIN) | 2207 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shafi, S. |
| 9 (RLIN) | 26312 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bashir, M. |
| 9 (RLIN) | 41107 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sharma, D. |
| 9 (RLIN) | 38508 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Field link and sequence number | 001712489 |
| Personal name | Qureshi, N. |
| Miscellaneous information | Global Wheat Program |
| 9 (RLIN) | 18145 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vishwakarma, M.K. |
| 9 (RLIN) | 2190 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kaur, S. |
| 9 (RLIN) | 41108 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kaur, J. |
| 9 (RLIN) | 29576 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bhati, P. K. |
| Field link and sequence number | 001710151 |
| Miscellaneous information | Borlaug Institute for South Asia |
| 9 (RLIN) | 26310 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kaur, S. |
| 9 (RLIN) | 24391 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khan, M.A. |
| 9 (RLIN) | 3274 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Varshney, R.K. |
| 9 (RLIN) | 5901 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mir, R. |
| 9 (RLIN) | 9206 |
| 773 0# - HOST ITEM ENTRY | |
| Title | Functional & Integrative Genomics |
| Related parts | v. 26, no. 1, art. 15 |
| Place, publisher, and date of publication | Germany : Springer, 2026. |
| International Standard Serial Number | 1438-793X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Article |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Date last seen | Total Checkouts | Price effective from | Koha item type | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Withdrawn status | Home library | Current library | Date acquired |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 01/12/2026 | 01/12/2026 | Article | Not Lost | Dewey Decimal Classification | CIMMYT Staff Publications Collection | CIMMYT Knowledge Center: John Woolston Library | CIMMYT Knowledge Center: John Woolston Library | 01/12/2026 |