Rumen and plasma metabolomics profiling by UHPLC-QTOF/MS revealed metabolic alterations associated with a high-corn diet in beef steers (Record no. 64712)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03386nab|a22003857a|4500 |
| 001 - CONTROL NUMBER | |
| control field | 64712 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211217225807.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211206s2018 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1932-6203 (Online) |
| 024 8# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | https://doi.org/10.1371/journal.pone.0208031 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MX-TxCIM |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | You Yang |
| 9 (RLIN) | 25956 |
| 245 10 - TITLE STATEMENT | |
| Title | Rumen and plasma metabolomics profiling by UHPLC-QTOF/MS revealed metabolic alterations associated with a high-corn diet in beef steers |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | San Francisco, CA (USA) : |
| Name of publisher, distributor, etc. | Public Library of Science |
| Date of publication, distribution, etc. | 2018. |
| 500 ## - GENERAL NOTE | |
| General note | Peer review |
| 500 ## - GENERAL NOTE | |
| General note | Open Access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | High-grain diets are strongly associated with metabolic disorders in beef steers. Metabolomics can be used to explore the relationship between diet and metabolic changes, but no study has reported rumen and plasma metabolomics profiling associated with increasing dietary corn proportions in the diet of beef steers. Therefore, 12 steers paired according to similar body weights and body condition scores were randomly allocated to one of two diets: a low-corn (28.76%) diet (LCD) with a 40:60 ratio of concentrate to roughage and a high-corn (48.76%) diet (HCD) with a 60:40 ratio of concentrate to roughage. Metabolomics profiling by ultra-high-performance liquid tandem chromatography quadrupole time of flight mass spectrometry (UHPLC-QTOF/MS) showed that steers fed the HCD had increased rumen and plasma carbohydrate metabolites and amino acids, which contributed to the growth of the beef steers. However, the rumen acidity and ruminal and plasma lipopolysaccharide (LPS) concentrations significantly increased with the increase amounts of corn in the diet. In total, 717 rumen metabolites and 386 plasma metabolites were identified. By multivariate analysis, 144 rumen and 56 plasma metabolites were further identified that were significantly different between the two groups (P < 0.05 and variable influence on projection > 1). The differential metabolites in the rumen and plasma were associated with different metabolic pathways, and phenylalanine, tyrosine and tryptophan biosynthesis and phenylalanine metabolism were common key metabolic pathways for the two biofluids. In conclusion, the high-corn diet improved the growth performance of beef steers but decreased the ruminal pH and increased the LPS and harmful metabolites in the rumen and blood, which has implications for the incidence of metabolic diseases. The identified differential metabolites in both the rumen and plasma and the related metabolic pathways may contribute to the exploration of potential biomarkers for high-corn diet-based metabolic diseases. |
| 546 ## - LANGUAGE NOTE | |
| Language note | Text in English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Diet |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 5374 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cattle |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 4376 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Metabolites |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 8948 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Beef |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 24148 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Amino acid metabolism |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 25957 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Phenylalanine |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 25958 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Guozhong Dong |
| 9 (RLIN) | 25959 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhi Wang |
| 9 (RLIN) | 18606 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jian Wang |
| 9 (RLIN) | 25102 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhu Zhang |
| 9 (RLIN) | 25960 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Junhui Liu |
| 9 (RLIN) | 25961 |
| 773 0# - HOST ITEM ENTRY | |
| Title | PLoS ONE |
| Related parts | v. 13, no. 11, e0208031 |
| Place, publisher, and date of publication | San Francisco, CA (USA) : Public Library of Science, 2018. |
| International Standard Serial Number | 1932-6203 |
| Record control number | G94957 |
| 856 4# - ELECTRONIC LOCATION AND ACCESS | |
| Link text | Click here to access online |
| Uniform Resource Identifier | https://doi.org/10.1371/journal.pone.0208031 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Article |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Date last seen | Total Checkouts | Price effective from | Koha item type | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Withdrawn status | Home library | Current library | Date acquired |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12/13/2021 | 12/13/2021 | Article | Not Lost | Dewey Decimal Classification | Reprints Collection | CIMMYT Knowledge Center: John Woolston Library | CIMMYT Knowledge Center: John Woolston Library | 12/13/2021 |