Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis (Record no. 64370)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03732nab|a22005297a|4500 |
| 001 - CONTROL NUMBER | |
| control field | 64370 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211015213350.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190823s2021||||xxk|||p|op||||00||0|eng|d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1741-7007 |
| 024 8# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | https://doi.org/10.1186/s12915-021-01094-1 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MX-TxCIM |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hadjirin, N.F. |
| 9 (RLIN) | 23881 |
| 245 1# - TITLE STATEMENT | |
| Title | Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | United Kingdom : |
| Name of publisher, distributor, etc. | BioMed Central, |
| Date of publication, distribution, etc. | 2021. |
| 500 ## - GENERAL NOTE | |
| General note | Peer review |
| 500 ## - GENERAL NOTE | |
| General note | Open Access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Antimicrobial resistance (AMR) is among the gravest threats to human health and food security worldwide. The use of antimicrobials in livestock production can lead to emergence of AMR, which can have direct effects on humans through spread of zoonotic disease. Pigs pose a particular risk as they are a source of zoonotic diseases and receive more antimicrobials than most other livestock. Here we use a large-scale genomic approach to characterise AMR in Streptococcus suis, a commensal found in most pigs, but which can also cause serious disease in both pigs and humans. Results: We obtained replicated measures of Minimum Inhibitory Concentration (MIC) for 16 antibiotics, across a panel of 678 isolates, from the major pig-producing regions of the world. For several drugs, there was no natural separation into ‘resistant’ and ‘susceptible’, highlighting the need to treat MIC as a quantitative trait. We found differences in MICs between countries, consistent with their patterns of antimicrobial usage. AMR levels were high even for drugs not used to treat S. suis, with many multidrug-resistant isolates. Similar levels of resistance were found in pigs and humans from regions associated with zoonotic transmission. We next used whole genome sequences for each isolate to identify 43 candidate resistance determinants, 22 of which were novel in S. suis. The presence of these determinants explained most of the variation in MIC. But there were also interesting complications, including epistatic interactions, where known resistance alleles had no effect in some genetic backgrounds. Beta-lactam resistance involved many core genome variants of small effect, appearing in a characteristic order. Conclusions: We present a large dataset allowing the analysis of the multiple contributing factors to AMR in S. suis. The high levels of AMR in S. suis that we observe are reflected by antibiotic usage patterns but our results confirm the potential for genomic data to aid in the fight against AMR. |
| 546 ## - LANGUAGE NOTE | |
| Language note | Text in English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 1134 |
| Topical term or geographic name as entry element | Genotypes |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 3634 |
| Topical term or geographic name as entry element | Phenotypes |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 4859 |
| Topical term or geographic name as entry element | Models |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 2466 |
| Topical term or geographic name as entry element | Ecology |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 23882 |
| Topical term or geographic name as entry element | Tiamulin |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 23883 |
| Topical term or geographic name as entry element | Trimethoprim |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 4363 |
| Topical term or geographic name as entry element | Swine |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Miller, E.L. |
| 9 (RLIN) | 23884 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Murray, G.G.R. |
| 9 (RLIN) | 23885 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Phung L. K. Yen |
| 9 (RLIN) | 23886 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ho D. Phuc |
| 9 (RLIN) | 23887 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wileman, T.M. |
| 9 (RLIN) | 23888 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hernandez-Garcia, J. |
| 9 (RLIN) | 23889 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Williamson, S.M. |
| 9 (RLIN) | 23890 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Parkhill, J. |
| 9 (RLIN) | 23891 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maskell, D.J. |
| 9 (RLIN) | 23892 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rui Zhou |
| 9 (RLIN) | 23893 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fittipaldi, N. |
| 9 (RLIN) | 23894 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gottschalk, M. |
| 9 (RLIN) | 23895 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tucker, A.W. |
| 9 (RLIN) | 23896 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ngo Thi Hoa |
| 9 (RLIN) | 23897 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Welch, J.J. |
| 9 (RLIN) | 23898 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Weinert, L.A. |
| 9 (RLIN) | 23899 |
| 773 0# - HOST ITEM ENTRY | |
| Title | BMC Biology |
| Related parts | v. 17, art. 191 |
| Place, publisher, and date of publication | United Kingdom : BioMed Central, 2021. |
| International Standard Serial Number | 1741-7007 |
| 856 4# - ELECTRONIC LOCATION AND ACCESS | |
| Link text | Click here to access online |
| Uniform Resource Identifier | https://doi.org/10.1186/s12915-021-01094-1 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Article |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Date last seen | Total Checkouts | Price effective from | Koha item type | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Withdrawn status | Home library | Current library | Date acquired |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/14/2021 | 10/14/2021 | Article | Not Lost | Dewey Decimal Classification | Reprints Collection | CIMMYT Knowledge Center: John Woolston Library | CIMMYT Knowledge Center: John Woolston Library | 10/14/2021 |