MARC details
| 000 -LEADER |
|---|
| fixed length control field |
00595nab|a22002177a|4500 |
| 001 - CONTROL NUMBER |
|---|
| control field |
64158 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20210902161143.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
201209s2021||||ne |||p|op||||00||0|eng|d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
2210-6359 |
| 024 8# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
https://doi.org/10.1186/s43008-021-00060-4 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
MX-TxCIM |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ruilin Sun |
| 9 (RLIN) |
22700 |
| 245 14 - TITLE STATEMENT |
|---|
| Title |
The Fungi-specific histone Acetyltransferase Rtt109 mediates morphogenesis, Aflatoxin synthesis and pathogenicity in Aspergillus flavus by acetylating H3K9 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Netherlands : |
| Name of publisher, distributor, etc. |
International Mycological Association, |
| Date of publication, distribution, etc. |
2021. |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Peer review |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Open Access |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Aspergillus flavus is a common saprophytic filamentous fungus that produces the highly toxic natural compound aflatoxin during its growth process. Synthesis of the aflatoxins, which can contaminate food crops causing huge losses to the agricultural economy, is often regulated by epigenetic modification, such as the histone acetyltransferase. In this study, we used Aspergillus flavus as an experimental model to construct the acetyltransferase gene rtt109 knockout strain (△rtt109) and its complementary strain (△rtt109·com) by homologous recombination. The growth of △rtt109 was significantly suppressed compared to the wild type (WT) strain and the △rtt109·com strain. The sclerotium of △rtt109 grew smaller, and the amount of sclerotia generated by △rtt109 was significantly reduced. The number of conidiums of △rtt109 was significantly reduced, especially on the yeast extract sucrose (YES) solid medium. The amount of aflatoxins synthesized by △rtt109 in the PDB liquid medium was significantly decreased We also found that the △rtt109 strain was extremely sensitive to DNA damage stress. Through the maize seed infection experiment, we found that the growth of △rtt109 on the surface of affected corn was largely reduced, and the amount of aerial mycelium decreased significantly, which was consistent with the results on the artificial medium. We further found that H3K9 was the acetylated target of Rtt109 in A. flavus. In conclusion, Rtt109 participated in the growth, conidium formation, sclerotia generation, aflatoxin synthesis, environmental stress response, regulation of infection of A. flavus. The results from this study of rtt109 showed data for acetylation in the regulation of life processes and provided a new thought regarding the prevention and control of A. flavus hazards. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Aspergillus flavus |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
5636 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Histones |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
22701 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Acetylation |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
16334 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Genes |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
3563 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Meifang Wen |
| 9 (RLIN) |
22702 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lianghuan Wu |
| 9 (RLIN) |
22703 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Huahui Lan |
| 9 (RLIN) |
22704 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Jun Yuan |
| 9 (RLIN) |
22705 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shihua Wang |
| 9 (RLIN) |
22706 |
| 773 0# - HOST ITEM ENTRY |
|---|
| Related parts |
v. 12, art. 9 |
| Place, publisher, and date of publication |
Netherlands : International Mycological Association, 2021. |
| International Standard Serial Number |
2210-6359 |
| Title |
IMA Fungus |
| 856 4# - ELECTRONIC LOCATION AND ACCESS |
|---|
| Link text |
Click here to access online |
| Uniform Resource Identifier |
https://doi.org/10.1186/s43008-021-00060-4 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Article |
| Suppress in OPAC |
No |
| Source of classification or shelving scheme |
Dewey Decimal Classification |