Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens (Record no. 63877)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03060nab|a22004097a|4500 |
| 001 - CONTROL NUMBER | |
| control field | 63877 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230313165819.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200910s2021||||xxk|||p|op||||00||0|eng|d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2049-2618 |
| 024 8# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | https://doi.org/10.1186/s40168-021-01077-y |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MX-TxCIM |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Jing Wang |
| 9 (RLIN) | 1646 |
| 245 10 - TITLE STATEMENT | |
| Title | Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | London (United Kingdom) : |
| Name of publisher, distributor, etc. | BioMed Central, |
| Date of publication, distribution, etc. | 2021. |
| 500 ## - GENERAL NOTE | |
| General note | Peer review |
| 500 ## - GENERAL NOTE | |
| General note | Open Access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Microbiome interactions are important determinants for ecosystem functioning, stability, and health. In previous studies, it was often observed that bacteria suppress potentially pathogenic fungal species that are part of the same plant microbiota; however, the underlying microbe-microbe interplay remains mostly elusive. Here, we explored antagonistic interactions of the fungus Fusarium graminearum and bacterium Streptomyces hygroscopicus at the molecular level. Both are ubiquitous members of the healthy wheat microbiota; under dysbiosis, the fungus causes devastating diseases. Results: In co-cultures, we found that Streptomyces alters the fungal acetylome leading to substantial induction of fungal autophagy. The bacterium secrets rapamycin to inactivate the target of rapamycin (TOR), which subsequently promotes the degradation of the fungal histone acetyltransferase Gcn5 through the 26S proteasome. Gcn5 negatively regulates fungal autophagy by acetylating the autophagy-related protein Atg8 at the lysine site K13 and blocking cellular relocalization of Atg8. Thus, degradation of Gcn5 triggered by rapamycin was found to reduce Atg8 acetylation, resulting in autophagy induction in F. graminearum. Conclusions: Autophagy homeostasis plays an essential role in fungal growth and competition, as well as for virulence. Our work reveals a novel post-translational regulation of autophagy initiated by a bacterial antibiotic. Rapamycin was shown to be a powerful modulator of bacteria–fungi interactions with potential importance in explaining microbial homeostasis in healthy plant microbiomes. The autophagic process provides novel possibilities and targets to biologically control pathogens. |
| 546 ## - LANGUAGE NOTE | |
| Language note | Text in English |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Microorganisms |
| Miscellaneous information | AGROVOC |
| 9 (RLIN) | 10080 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 1017 |
| Topical term or geographic name as entry element | Bacteria |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Fungi |
| Miscellaneous information | AGROVOC |
| Source of heading or term | |
| 9 (RLIN) | 1121 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 2331 |
| Topical term or geographic name as entry element | Gibberella zeae |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 20578 |
| Topical term or geographic name as entry element | Streptomyces |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20579 |
| Personal name | Chaoyun Xu |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20580 |
| Personal name | Qiming Sun |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20581 |
| Personal name | Jinrong Xu |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20582 |
| Personal name | Yunrong Chai |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20583 |
| Personal name | Berg, G. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20584 |
| Personal name | Cernava, T. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20585 |
| Personal name | Zhonghua Ma |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20586 |
| Personal name | Yun Chen |
| 773 0# - HOST ITEM ENTRY | |
| Title | Microbiome |
| Related parts | v. 9, art. 131 |
| Place, publisher, and date of publication | London (United Kingdom) : BioMed Central, 2021. |
| International Standard Serial Number | 2049-2618 |
| 856 4# - ELECTRONIC LOCATION AND ACCESS | |
| Link text | Click here to access online |
| Uniform Resource Identifier | https://doi.org/10.1186/s40168-021-01077-y |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Article |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Date last seen | Total Checkouts | Price effective from | Koha item type | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Withdrawn status | Home library | Current library | Date acquired |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 06/25/2021 | 06/25/2021 | Article | Not Lost | Dewey Decimal Classification | Reprints Collection | CIMMYT Knowledge Center: John Woolston Library | CIMMYT Knowledge Center: John Woolston Library | 06/25/2021 |