MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03769nab|a22004217a|4500 |
| 001 - CONTROL NUMBER |
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| control field |
62962 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20211027200258.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201202s2020||||xxu|||p|op||||00||0|eng|d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
0022-3166 |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
1541-6100 (Online) |
| 024 8# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
https://doi.org/10.1093/jn/nxaa142 |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
MX-TxCIM |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sowa, M. |
| 9 (RLIN) |
6167 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Overlapping vitamin A interventions with provitamin A carotenoids and preformed vitamin A cause excessive liver retinol stores in male Mongolian gerbils |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Bethesda, MD (USA) : |
| Name of publisher, distributor, etc. |
American Society for Nutrition : |
| -- |
Oxford University Press, |
| Date of publication, distribution, etc. |
2020. |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Peer review |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background. Vitamin A (VA) deficiency is a public health problem in some countries. Fortification, supplementation, and increased provitamin A consumption through biofortification are efficacious, but monitoring is needed due to risk of excessive VA intake when interventions overlap. Objectives. Two studies in 28–36-d-old male Mongolian gerbils simulated exposure to multiple VA interventions to determine the effects of provitamin A carotenoid consumption from biofortified maize and carrots and preformed VA fortificant on status. Methods. Study 1 was a 2 × 2 × 2 factorial design (n = 85) with high-β-carotene maize, orange carrots, and VA fortification at 50% estimated gerbil needs, compared with white maize and white carrot controls. Study 2 was a 2 × 3 factorial design (n = 66) evaluating orange carrot and VA consumption through fortification at 100% and 200% estimated needs. Both studies utilized 2-wk VA depletion, baseline evaluation, 9-wk treatments, and liver VA stores by HPLC. Intestinal scavenger receptor class B member 1 (Scarb1), β-carotene 15,15′-dioxygenase (Bco1), β-carotene 9′,10′-oxygenase (Bco2), intestine-specific homeobox (Isx), and cytochrome P450 26A1 isoform α1 (Cyp26a1) expression was analyzed by qRT-PCR in study 2. Results. In study 1, liver VA concentrations were significantly higher in orange carrot (0.69 ± 0.12 μmol/g) and orange maize groups (0.52 ± 0.21 μmol/g) compared with baseline (0.23 ± 0.069 μmol/g) and controls. Liver VA concentrations from VA fortificant alone (0.11 ± 0.053 μmol/g) did not differ from negative control. In study 2, orange carrot significantly enhanced liver VA concentrations (0.85 ± 0.24 μmol/g) relative to baseline (0.43 ± 0.14 μmol/g), but VA fortificant alone (0.42 ± 0.21 μmol/g) did not. Intestinal Scarb1 and Bco1 were negatively correlated with increasing liver VA concentrations (P < 0.01, r2 = 0.25–0.27). Serum retinol concentrations did not differ. Conclusions.Biofortified carrots and maize without fortification prevented VA deficiency in gerbils. During adequate provitamin A dietary intake, preformed VA intake resulted in excessive liver stores in gerbils, despite downregulation of carotenoid absorption and cleavage gene expression. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Food fortification |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
9710 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Maize |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
1173 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Carotenes |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
8110 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Carrots |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
17366 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Retinol |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
1241 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mourao, L. |
| 9 (RLIN) |
3596 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sheftel, J. |
| 9 (RLIN) |
8112 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kaeppler, M. |
| 9 (RLIN) |
17367 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Simons, G. |
| 9 (RLIN) |
17368 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Grahn, M. |
| 9 (RLIN) |
3993 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Davis, C.R. |
| 9 (RLIN) |
3597 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lintig, J. von |
| 9 (RLIN) |
11814 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Simon, P. |
| 9 (RLIN) |
3598 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Pixley, K.V. |
| 9 (RLIN) |
832 |
| Field link and sequence number |
INT1617 |
| Miscellaneous information |
Genetic Resources Program |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tanumihardjo, S. A. |
| 9 (RLIN) |
330 |
| 773 0# - HOST ITEM ENTRY |
|---|
| Related parts |
v. 150, no. 11, p. 2912-2923 |
| Place, publisher, and date of publication |
Bethesda, MD (USA) : American Society for Nutrition : Oxford University Press, 2020. |
| International Standard Serial Number |
0022-3166 |
| Title |
The Journal of Nutrition |
| Record control number |
u444562 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Article |
| Suppress in OPAC |
No |
| Source of classification or shelving scheme |
Dewey Decimal Classification |