Tetrahydroquinolinyl phosphinamidates and phosphonamidates enhancing tolerance towards drought stress in crops via interaction with ABA receptor proteins (Record no. 62645)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 00595nab|a22002177a|4500 |
| 001 - CONTROL NUMBER | |
| control field | 62645 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20201002223537.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200910s2020||||xxk|||p|op||||00||0|eng|d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0968-0896 |
| 024 8# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | https://doi.org/10.1016/j.bmc.2020.115725 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | MX-TxCIM |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Frackenpohl, J. |
| 9 (RLIN) | 16212 |
| 245 10 - TITLE STATEMENT | |
| Title | Tetrahydroquinolinyl phosphinamidates and phosphonamidates enhancing tolerance towards drought stress in crops via interaction with ABA receptor proteins |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | United Kingom : |
| Name of publisher, distributor, etc. | Elsevier, |
| Date of publication, distribution, etc. | 2020. |
| 500 ## - GENERAL NOTE | |
| General note | Peer review |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | New phosphorous-containing lead structures against drought stress in crops interacting with RCAR/(PYR/PYL) receptor proteins were identified starting from in-depth SAR studies of related sulfonamide lead structures and protein docking studies. A converging 6-step synthesis via phosphinic chlorides and phosphono chloridates as key intermediates afforded envisaged tetrahydroquinolinyl phosphinamidates and phosphonamidates. Whilst tetrahydroquinolinyl phosphonamidates 13a,b exhibited low to moderate target affinities, the corresponding tetrahydroquinolinyl phosphinamidates 12a,b revealed confirmed strong affinities for RCAR/ (PYR/PYL) receptor proteins in Arabidopsis thaliana on the same level as essential plant hormone abscisic acid (ABA) combined with promising efficacy against drought stress in vivo (broad-acre crops wheat and canola). |
| 546 ## - LANGUAGE NOTE | |
| Language note | Text in English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 11179 |
| Topical term or geographic name as entry element | Phytochemistry |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 1081 |
| Topical term or geographic name as entry element | Drought stress |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Source of heading or term | AGROVOC |
| 9 (RLIN) | 3517 |
| Topical term or geographic name as entry element | ABA |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16213 |
| Personal name | Decker, L.J.B. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16214 |
| Personal name | Dittgen, J. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16215 |
| Personal name | Freigang, J. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16216 |
| Personal name | Génix, P. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16217 |
| Personal name | Helmke, H. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16218 |
| Personal name | Lange, G. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16219 |
| Personal name | Luemmen, P. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16220 |
| Personal name | Schmidt, J. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16221 |
| Personal name | Schmutzler, D. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16222 |
| Personal name | Vors, J. |
| 773 0# - HOST ITEM ENTRY | |
| Title | Bioorganic and Medicinal Chemistry |
| Related parts | v. 28, no. 22, art. 115725 |
| Place, publisher, and date of publication | United Kingdom : Elsevier, 2020. |
| International Standard Serial Number | 0968-0896 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Article |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Date last seen | Total Checkouts | Price effective from | Koha item type | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Withdrawn status | Home library | Current library | Date acquired |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/30/2020 | 09/30/2020 | Article | Not Lost | Dewey Decimal Classification | Reprints Collection | CIMMYT Knowledge Center: John Woolston Library | CIMMYT Knowledge Center: John Woolston Library | 09/30/2020 |