MARC details
| 000 -LEADER |
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| fixed length control field |
02448nab a22003737a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
61979 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20200601165226.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180103s2013 gw |||p|op||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0040-5752 |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1432-2242 (Online) |
| 024 8# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
https://doi.org/10.1007/s00122-013-2064-2 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
MX-TxCIM |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
7797 |
| Personal name |
Gianola, D. |
| 245 10 - TITLE STATEMENT |
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| Title |
Contribution of an additive locus to genetic variance when inheritance is multi-factorial with implications on interpretation of GWAS |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc. |
Berlin (Germany) : |
| Name of publisher, distributor, etc. |
Springer, |
| Date of publication, distribution, etc. |
2013. |
| 500 ## - GENERAL NOTE |
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| General note |
Peer review |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Although the effects of linkage disequilibrium (LD) on partition of genetic variance have received attention in quantitative genetics, there has been little discussion on how this phenomenon affects attribution of variance to a given locus. This paper reinforces the point that standard metrics used for assessing the contribution of a locus to variance can be misleading when there is linkage LD and that factors such as distribution of effects and of allelic frequencies over loci, or existence of frequency-dependent effects, play a role as well. An apparently new metric is proposed for measuring how much of the variability is contributed by a locus when LD exists. Effects of intervening factors, such as type and extent of LD, number of loci, distribution of effects, and of allelic frequencies over loci, as well as a model for generating frequency-dependent effects, are illustrated via hypothetical simulation scenarios. Implications on the interpretation of genome-wide association studies (GWAS), as typically carried out in human genetics, where single marker regression and the assumption of a sole quantitative trait locus (QTL) are common, are discussed. It is concluded that the standard attributions to variance contributed by a single QTL from a GWAS analysis may be misleading, conceptually and statistically, when a trait is complex and affected by sets of many genes in linkage disequilibrium. Yet another factor to consider in the “missing heritability” saga?. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
Text in English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
1853 |
| Topical term or geographic name as entry element |
Quantitative Trait Loci |
| Source of heading or term |
AGROVOC |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
10050 |
| Topical term or geographic name as entry element |
Genetic linkage |
| Source of heading or term |
AGROVOC |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
13593 |
| Personal name |
Hospital, F. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
13594 |
| Personal name |
Verrier, E. |
| 773 0# - HOST ITEM ENTRY |
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| Related parts |
v. 126, no. 6, p. 1457-1472 |
| Title |
Theoretical and Applied Genetics |
| International Standard Serial Number |
0040-5752 |
| Place, publisher, and date of publication |
Berlin (Germany) : Springer, 2013. |
| Record control number |
u444762 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Article |
| Suppress in OPAC |
No |