MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03063nab a22003737a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
60280 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20240524212653.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190321s2018 ne ||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0378-1119 |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
https://doi.org/10.1016/j.gene.2018.08.041 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
MX-TxCIM |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8791 |
| Personal name |
Domínguez-Cruz, M.G. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Pilot genome-wide association study identifying novel risk loci for type 2 diabetes in a Maya population |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Amsterdam (Netherlands) : |
| Name of publisher, distributor, etc. |
Elsevier, |
| Date of publication, distribution, etc. |
2018. |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Peer Review |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Type 2 diabetes mellitus (T2D) is one of the two leading causes of mortality in Mexico. However, most studies have focused on Caucasians or Asians, and there are a small number of studies investigating Maya populations. Furthermore, to the best of our knowledge, there is no information on isolated Maya communities with T2D frequencies of 20% that are primarily attributed to ethnicity. Consequently, this study focused on assessing which genetic risk variants could be involved in the high rates of T2D in 92 individuals with Maya ancestry; 47 were diagnosed with T2D, and 45 were classified as healthy individuals. A pilot genome-wide association study was performed using the Affymetrix Axiom Genome-wide LAT1 array. The population structure was determined with the ADMIXTURE software using 1289 Latin American selected polymorphisms, and 39 polymorphisms associated with T2D were included for replication. Association tests were performed using the Statistical Analysis System (SAS) using the allelic, genotype and Armitage trend tests. The results indicated that population structure analysis displayed no differences between T2D patients and healthy individuals; 24 loci located were identified for probable association with T2D (p > 1.288 × 10−7 and p < 1.348 × 10−4); the polymorphism AGTR2 rs1914711 in chromosome X was identified by the allele test (OR = 6.824; p = 1.448 × 10−9) as a candidate gene for association with T2D; and ARL15 rs4311394 was associated as a T2D protector by genotype and the Armitage trend test (OR = 0.318; p = 0.001). In conclusion, this study proposes 24 candidate SNPs associated with T2D for replication studies and one for protective association with T2D. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
7612 |
| Topical term or geographic name as entry element |
Diabetes |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
1126 |
| Topical term or geographic name as entry element |
Genetic polymorphism |
| Source of heading or term |
AGROVOC |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
3563 |
| Topical term or geographic name as entry element |
Genes |
| 651 #7 - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
1318 |
| Geographic name |
Mexico |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
7613 |
| Personal name |
Muñoz, M. de L. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
7610 |
| Personal name |
Totomoch-Serra, A. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8792 |
| Personal name |
García-Escalante, M.G. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
907 |
| Personal name |
Burgueño, J. |
| Miscellaneous information |
Genetic Resources Program |
| Field link and sequence number |
INT3239 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8793 |
| Personal name |
Valadez-González, N. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Pinto-Escalante, D. |
| 9 (RLIN) |
8794 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
7617 |
| Personal name |
Diaz-Badillo, A. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Place, publisher, and date of publication |
Amsterdam (Netherlands) : Elsevier, 2018. |
| Related parts |
vol. 677, p. 324-331 |
| Title |
Gene |
| International Standard Serial Number |
0378-1119 |
| 856 4# - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
https://libcatalog.cimmyt.org/Download/cis/60280.pdf |
| Link text |
Access only for CIMMYT Staff |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Article |
| Suppress in OPAC |
No |