MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02941nab a22004097a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
60015 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20211006082417.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190124s2018 sz |||po|p||| 00| 0 eng d |
| 024 8# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
https://doi.org/10.3389/fpls.2018.01196 |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
MX-TxCIM |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8338 |
| Personal name |
Yanchun Peng |
| 245 1# - TITLE STATEMENT |
|---|
| Title |
Genome-wide association studies of free amino acid levels by six multi-locus models in bread wheat |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Switzerland : |
| Name of publisher, distributor, etc. |
Frontiers, |
| Date of publication, distribution, etc. |
2018. |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Peer review |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Open Access |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Genome-wide association studies (GWAS) have been widely used to dissect the complex biosynthetic processes of plant metabolome. Most studies have used single-locus GWAS approaches, such as mixed linear model (MLM), and little is known about more efficient algorithms to implement multi-locus GWAS. Here, we report a comprehensive GWAS of 20 free amino acid (FAA) levels in kernels of bread wheat (Triticum aestivum L.) based on 14,646 SNPs by six multi-locus models (FASTmrEMMA, FASTmrMLM, ISISEM-BLASSO, mrMLM, pKWmEB, and pLARmEB). Our results showed that 328 significant quantitative trait nucleotides (QTNs) were identified in total (38, 8, 92, 45, 117, and 28, respectively, for the above six models). Among them, 66 were repeatedly detected by more than two models, and 155 QTNs appeared only in one model, indicating the reliability and complementarity of these models. We also found that the number of significant QTNs for different FAAs varied from 8 to 41, which revealed the complexity of the genetic regulation of metabolism, and further demonstrated the necessity of the multi-locus GWAS. Around these significant QTNs, 15 candidate genes were found to be involved in FAA biosynthesis, and one candidate gene (TraesCS1D01G052500, annotated as tryptophan decarboxylase) was functionally identified to influence the content of tryptamine in vitro. Our study demonstrated the power and efficiency of multi-locus GWAS models in crop metabolome research and provided new insights into understanding FAA biosynthesis in wheat. |
| 526 ## - STUDY PROGRAM INFORMATION NOTE |
|---|
| Program name |
Wheat CRP |
| Wheat Flagship Projects |
FP2 - Novel diversity and tools adapt to climate change and resource constraints |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English |
| 591 ## - CATALOGING NOTES |
|---|
| Affiliation |
He Zhonghu : No CIMMYT Affiliation |
| 591 ## - CATALOGING NOTES |
|---|
| Affiliation |
Yuanfeng Hao : Not CIMMYT Affiliation, not IRS Staff list but CIMMYT Staff member |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
1265 |
| Topical term or geographic name as entry element |
Soft wheat |
| Source of heading or term |
AGROVOC |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
8344 |
| Topical term or geographic name as entry element |
Free amino acids |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
5832 |
| Topical term or geographic name as entry element |
Genomic features |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8339 |
| Personal name |
Hongbo Liu |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8340 |
| Personal name |
Jie Chen |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8341 |
| Personal name |
Taotao Shi |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8342 |
| Personal name |
Chi Zhang |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8343 |
| Personal name |
Dongfa Sun |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
He Zhonghu |
| Miscellaneous information |
Global Wheat Program |
| Field link and sequence number |
INT2411 |
| 9 (RLIN) |
838 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Field link and sequence number |
INT3329 |
| 9 (RLIN) |
919 |
| Personal name |
Yuanfeng Hao |
| Miscellaneous information |
Global Wheat Program |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
2613 |
| Personal name |
Wei Chen |
| 773 0# - HOST ITEM ENTRY |
|---|
| Related parts |
v. 9, art. 1196 |
| Title |
Frontiers in Plant Science |
| Record control number |
u56875 |
| International Standard Serial Number |
1664-462X |
| 856 4# - ELECTRONIC LOCATION AND ACCESS |
|---|
| Link text |
Open Access through DSpace |
| Uniform Resource Identifier |
https://hdl.handle.net/10883/19893 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Article |
| Suppress in OPAC |
No |