MARC details
| 000 -LEADER |
|---|
| fixed length control field |
nab a22 7a 4500 |
| 001 - CONTROL NUMBER |
|---|
| control field |
59587 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20191119220136.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
180604s2018||||ne |||p|op||||00||0|eng|d |
| 024 8# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
https://doi.org/10.1016/j.gene.2018.05.078 |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
MX-TxCIM |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Totomoch-Serra, A. |
| 9 (RLIN) |
7610 |
| 245 14 - TITLE STATEMENT |
|---|
| Title |
The ADRA2A rs553668 variant is associated with type 2 diabetes and five variants were associated at nominal significance levels in a population-based case–control study from Mexico City |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Name of publisher, distributor, etc. |
Elsevier, |
| Date of publication, distribution, etc. |
2018. |
| Place of publication, distribution, etc. |
Amsterdam, Netherlands : |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Peer review |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Type 2 diabetes (T2D) is a disease with a prevalence of 9.4% in Mexicans. Its etiology is complex involving environmental and genetic factors. The aim of this study was to analyse the association between PPARG rs1801282, PPARGC1A rs8192678, VEGFA rs2010963, ADRA2A rs553668, KCNQ1 rs2237892, SIRT1 rs7896005, IGF2BP2 rs4402960, and UCP3 rs3781907 single nucleotide variants (SNVs) with T2D and metabolic traits in a case-control study of a population from Mexico City. A total of 831 blood samples of non-diabetic, with healthy control participants (416) and individuals with T2D (415) were collected over a five-year period. After DNA extraction, genotyping was performed with TaqMan probes using real-time PCR. The genotypes were analysed for association with T2D in linear and logistic regressions adjusting for age, sex, and body mass index using the dominant, recessive, and additive models with a Bonferroni correction for multiple comparisons p < 0.001 and for association with related T2D traits fixed with a p < 2.3 × 10?4. The univariate analysis gives a significant (p < 1 × 10?4) for sex, triglycerides, and HOMA-IR. Significant association with T2D was found for ADRA2A rs553668 under the recessive model (OR = 3.640 and 95% CI of 2.330?5.690 (p < 1 × 10?4); statistical power 0.999) and under the additive model (OR = 1.640 and 95% CI of 1.340?2.000 (p < 1 × 10?4); statistical power 0.997). Variants PPARG rs1801282, PPARGC1A rs8192678, SIRT1 rs7896005, IGF2BP2 rs4402960 and UCP3 rs3781907 were nominally associated (p > 0.001 and <0.050). Results describe association of ADRA2A rs553668 with T2D in a Mexican population. Variants with nominal association with T2D require to be replicated in additional Mexican populations. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English |
| 591 ## - CATALOGING NOTES |
|---|
| Number of CIMMYT Informa |
CIMMYT Informa : 2016 (July 5, 2018) |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
7611 |
| Topical term or geographic name as entry element |
Variants |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
7612 |
| Topical term or geographic name as entry element |
Diabetes |
| 651 #7 - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| 9 (RLIN) |
1318 |
| Geographic name |
Mexico |
| Source of heading or term |
AGROVOC |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Muñoz, M. de L. |
| 9 (RLIN) |
7613 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
907 |
| Personal name |
Burgueño, J. |
| Miscellaneous information |
Genetic Resources Program |
| Field link and sequence number |
INT3239 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Revilla-Monsalve, M.C. |
| 9 (RLIN) |
7615 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Perez-Muñoz, A. |
| 9 (RLIN) |
7616 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Diaz-Badillo, A. |
| 9 (RLIN) |
7617 |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Gene |
| Related parts |
v. 669, p. 28-34 |
| International Standard Serial Number |
0378-1119 |
| 856 4# - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
https://libcatalog.cimmyt.org/Download/cis/59587.pdf |
| Link text |
Access only for CIMMYT Staff |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Article |
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Suppress in OPAC |
No |