MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03617nab a22003977a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
57971 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20211006085129.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
150427s2016 xxu|||p|op||| 00| 0 eng d |
| 024 8# - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
https://doi.org/10.3945/jn.114.204933 |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
MX-TxCIM |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
500 |
| Personal name |
Gannon, B. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
13C natural abundance of serum retinol is a novel biomarker for evaluating provitamin A carotenoid-biofortified maize consumption in male Mongolian gerbils |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
USA : |
| Name of publisher, distributor, etc. |
American Society for Nutrition, |
| Date of publication, distribution, etc. |
2016. |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Peer review |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Open Access |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Crops such as maize, sorghum, and millet are being biofortified with provitamin A carotenoids to ensure adequate vitamin A (VA) intakes. VA assessment can be challenging because serum retinol concentrations are homeostatically controlled and more sensitive techniques are resource-intensive. Objectives: We investigated changes in serum retinol relative differences of isotope amount ratios of 13C/12C (d13C) caused by natural 13C fractionation in C3 compared with C4 plants as a biomarker to detect provitamin A efficacy from biofortified (orange) maize and high-carotene carrots. Methods: The design was a 2 3 2 3 2 maize (orange compared with white) by carrot (orange compared with white) by a VA fortificant (VA+ compared with VA2) in weanling male Mongolian gerbils (n = 55), which included a 14-d VA depletion period and a 62-d treatment period (1 baseline and 8 treatment groups; n = 527/group). Liver VA and serum retinol were quantified, purified by HPLC, and analyzed by GC combustion isotope ratio mass spectrometry for 13C. Results: Treatments affected liver VA concentrations (0.048 6 0.039 to 0.79 6 0.24 mmol/g; P < 0.0001) but not overall serum retinol concentrations (1.3860.22 mmol/L). Serum retinol and liver VA d13C were significantly correlated (R2 = 0.92; P < 0.0001). Serum retinol d13C differentiated control groups that consumed white maize and white carrots (227.1 6 1.2 d13C&) from treated groups that consumed orange maize and white carrots (221.6 6 1.4 d13C&; P < 0.0001) and white maize and orange carrots (230.6 6 0.7 d13C&; P < 0.0001). A prediction model demonstrated the relative contribution of orange maize to total dietary VA for groups that consumed VA from mixed sources. Conclusions: Provitamin A efficacy and quantitative estimation of the relative contribution to dietary VA were demonstrated with the use of serum retinol d13C. This method could be used for maize efficacy or effectiveness studies and with other C4 crops biofortified with provitamin A carotenoids (e.g., millet, sorghum). Advantages include no extrinsic tracer dose, 1 blood sample, and higher sensitivity than serum retinol concentrations alone. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in english. |
| 591 ## - CATALOGING NOTES |
|---|
| Number of CIMMYT Informa |
CIMMYT Informa: 1973 (August 18, 2016) |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Retinol |
| 9 (RLIN) |
1241 |
| Source of heading or term |
AGROVOC |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Maize |
| Miscellaneous information |
AGROVOC |
| Source of heading or term |
|
| 9 (RLIN) |
1173 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Provitamins |
| 9 (RLIN) |
1226 |
| Source of heading or term |
AGROVOC |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Cereal crops |
| 9 (RLIN) |
6794 |
| Source of heading or term |
AGROVOC |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Carotenoids |
| 9 (RLIN) |
1032 |
| Source of heading or term |
AGROVOC |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Isotope analysis |
| 9 (RLIN) |
2865 |
| Source of heading or term |
AGROVOC |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Pungarcher, I. |
| 9 (RLIN) |
3595 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mourao, L. |
| 9 (RLIN) |
3596 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Davis, C.R. |
| 9 (RLIN) |
3597 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
3598 |
| Personal name |
Simon, P. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
832 |
| Personal name |
Pixley, K.V. |
| Miscellaneous information |
Genetic Resources Program |
| Field link and sequence number |
INT1617 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
330 |
| Personal name |
Tanumihardjo, S. A. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Record control number |
u444562 |
| International Standard Serial Number |
0022-3166 |
| Place, publisher, and date of publication |
Bethesda, MD (USA) : American Institute of Nutrition |
| Title |
The Journal of Nutrition |
| Related parts |
v. 146, p. 1290-1297 |
| 856 4# - ELECTRONIC LOCATION AND ACCESS |
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| Link text |
Open Access through DSpace |
| Uniform Resource Identifier |
http://hdl.handle.net/10883/17150 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Article |
| Suppress in OPAC |
No |