MARC details
| 000 -LEADER |
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| fixed length control field |
04177nab a22003977a 4500 |
| 001 - CONTROL NUMBER |
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| control field |
G98312 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
MX-TxCIM |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20211006074749.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210611s2013 cc |||p|op||| 00| 0 chi d |
| 022 0# - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0496-3490 |
| 024 8# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
https://doi.org/10.3724/SP.J.1006.2013.00001 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
MX-TxCIM |
| 041 ## - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
chi |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
CIS-7406 |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sun Zi-Qi |
| 9 (RLIN) |
20225 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Properties of the test statistic under null hypothesis and the calculation of lod threshold in quantitative trait loci (qtl) mapping |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc. |
Beijing (China) : |
| Name of publisher, distributor, etc. |
Science Press, |
| Date of publication, distribution, etc. |
2013. |
| 500 ## - GENERAL NOTE |
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| General note |
Peer review |
| 500 ## - GENERAL NOTE |
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| General note |
Open Access |
| 500 ## - GENERAL NOTE |
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| General note |
Abstract in Chinese and English |
| 500 ## - GENERAL NOTE |
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| General note |
Peer-review: No - Open Access: Yes|http://211.155.251.148:8080/zwxb/EN/column/column81.shtml |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Selecting an appropriate LOD threshold is of great interest in QTL mapping studies. Many approaches can be considered to calculate the critical value throughout a genome, such as simulation-based method, analytical approximation, and empirical method based on permutation test. Many tests are conducted in QTL mapping, which are not mutually independent because the linkage relationship of adjacent markers on chromosomes. In order to declare a significant QTL at a genome-wide significance level, it is necessary to understand the behavior of test statistic under null hypothesis in QTL mapping and to deal with the dependent multiple-test problem arising in the genome-wide test. Our objectives in this study were (1) to investigate the properties of LRT (likelihood ratio test) statistic of one-point scanning under null hypothesis in QTL mapping, (2) to determine the factors affecting the cumulative distribution of maximum LOD score, and (3) to identify the relationship between the effective number of independent tests and the length of chromosome by simulation method. Results indicated that the LRT test statistic in one-dimensional scanning of additive-dominant QTL and two-dimensional scanning of epistatic QTL followed chi-square distributions, and the degree of freedom (df) was equal to the number of genetic parameters to be estimated. For example, degree of freedom in recombinant inbred lines (RIL) population was equal to 1 in one dimensional or two dimensional scanning. Degree of freedom in F2 populations was equal to 2 in one-dimensional scanning and 4 in two-dimensional scanning. Number of chromosome, population size and phenotyping error variance did not have any effect on the distribution of LRT under null hypothesis, and therefore will not affect the selection of LOD threshold. On the contrary, population type, genome size and marker density had significant impacts. For BC1, RIL and F2 populations, the threshold was the smallest in BC1 population and the highest in F2 population. Higher marker density and longer chromosome resulted in higher LOD threshold. It was identified that the effective number of independent tests (Meff) was proportional to the length of chromosome in one-dimensional scanning of additive-dominant QTL. In two-dimensional scanning of epistatic QTL, it was identified that Meffwas in a squared relationship to the length of chromosome. With the help of Bonferroni correction, we could acquire the relationship between point-wise and genome-wide significance levels. Therefore, it is convenient to calculate the threshold LOD in QTL mapping, given the genome-wide significance level, the population type, marker density and genome size. |
| 536 ## - FUNDING INFORMATION NOTE |
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| Text of note |
Genetic Resources Program |
| 546 ## - LANGUAGE NOTE |
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| Language note |
Text in English |
| 594 ## - STAFFID |
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| StaffID |
CLIH01|CLUZ01|INT2542 |
| 595 ## - COLLECTION |
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| Collection |
CIMMYT Staff Publications Collection |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Chromosome mapping |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
2084 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Quantitative Trait Loci |
| Source of heading or term |
AGROVOC |
| 9 (RLIN) |
1853 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Genomes |
| Miscellaneous information |
AGROVOC |
| Source of heading or term |
|
| 9 (RLIN) |
1131 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Huihui Li |
| Field link and sequence number |
CLIH01 |
| 9 (RLIN) |
764 |
| Miscellaneous information |
Genetic Resources Program |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Luyan Zhang |
| 9 (RLIN) |
1387 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Jiankang Wang |
| Field link and sequence number |
INT2542 |
| 9 (RLIN) |
842 |
| Miscellaneous information |
Genetic Resources Program |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Acta Agronomica Sinica |
| Related parts |
v. 39, no. 1, p. 1-11 |
| Place, publisher, and date of publication |
Beijing (China) : Science Press, 2013. |
| Record control number |
G446116 |
| International Standard Serial Number |
0496-3490 |
| 856 4# - ELECTRONIC LOCATION AND ACCESS |
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| Link text |
Open Access through DSpace |
| Uniform Resource Identifier |
https://hdl.handle.net/10883/21547 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Article |
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Suppress in OPAC |
No |